Salvini Camilla, Massi Daniela, Cappetti Alessio, Stante Marcello, Cappugi Pietro, Fabbri Paolo, Carli Paolo
Department of Dermatology, University of Florence, Florence, Italy.
Skin Res Technol. 2008 Feb;14(1):89-92. doi: 10.1111/j.1600-0846.2007.00265.x.
Optical coherence tomography (OCT) is a new non-invasive approach for real-time in vivo tissue characterization. A promising use of OCT can be the assessment of the architecture of lesions with some degree of inhomogeneities, such as vascular lesions. Knowledge of the size and depth of the vascular structures can be useful for the diagnosis and for choosing the best treatment.
The purpose of this study was to investigate a series of vascular lesions by means of OCT in order to obtain new insights into the non-invasive, pre-operative analysis of these lesions.
Seven vascular lesions were included in the study. Histopathological diagnosis showed two haemangiomas and one haemolymphangioma; the remaining four cases were classified as haemangiomas on the basis of their clinical appearance.
In all lesions, OCT analysis was able to visualize different areas of the lesion from the horny layer to the dermis showing a clear image of the vascular proliferation. Specifically, oval to roundish signal-poor areas sharply demarcated by a surrounding signal-rich layer were observed in good correlation with histopathology.
The analysis of vascular lesions by OCT provides a new insight into non-invasive diagnosis and can be helpful in the selection of the most appropriate treatment.
光学相干断层扫描（OCT）是一种用于实时体内组织特征分析的新型非侵入性方法。OCT的一个有前景的应用是评估具有一定程度不均匀性的病变结构，如血管病变。了解血管结构的大小和深度对于诊断和选择最佳治疗方法可能有用。
本研究旨在通过OCT对一系列血管病变进行研究，以便对这些病变的非侵入性术前分析获得新的见解。
本研究纳入了7例血管病变。组织病理学诊断显示2例血管瘤和1例血管淋巴管瘤；其余4例根据临床表现分类为血管瘤。
在所有病变中，OCT分析能够从角质层到真皮可视化病变的不同区域，显示出血管增生的清晰图像。具体而言，观察到椭圆形至圆形的信号贫乏区域被周围信号丰富的层清晰界定，与组织病理学具有良好的相关性。
通过OCT对血管病变进行分析为非侵入性诊断提供了新的见解，并且有助于选择最合适的治疗方法。
