Ahmed Samrah, Mitchell Joanna, Arnold Robert, Nestor Peter J, Hodges John R
Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK.
Dement Geriatr Cogn Disord. 2008;25(2):170-7. doi: 10.1159/000113014. Epub 2008 Jan 22.
BACKGROUND/AIMS: We investigated whether an initial neuropsychological assessment could predict rapid progression over 12 months, from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD).
A longitudinal study compared the neuropsychological profiles of 27 normal controls and 18 aMCI patients at baseline and 12 months.
At 12 months, 24 control subjects followed up remained cognitively normal. 7 aMCI patients (6 multiple-domain aMCI and 1 single-domain aMCI) progressed to AD, and 11 were non-progressors. Prognosis was best captured by a combination of associative learning, the paired associate learning task (PAL), and global cognition, the Addenbrooke's Cognitive Examination (ACE).
The PAL and ACE can sensitively detect meaningful differences in scores at baseline and may be used as prognostic indicators. Multiple-domain aMCI patients progressed rapidly to AD and may be more usefully labelled as early stage AD.
背景/目的：我们研究了初始神经心理学评估是否能够预测12个月内从遗忘型轻度认知障碍（aMCI）进展为阿尔茨海默病（AD）的快速进展情况。
一项纵向研究比较了27名正常对照者和18名aMCI患者在基线和12个月时的神经心理学概况。
在12个月时，24名接受随访的对照者认知仍正常。7名aMCI患者（6名多领域aMCI和1名单领域aMCI）进展为AD，11名未进展。联合学习（配对联想学习任务，PAL）和整体认知（Addenbrooke认知检查，ACE）相结合能最好地预测预后。
PAL和ACE能够灵敏地检测出基线时分数的有意义差异，可用作预后指标。多领域aMCI患者快速进展为AD，或许更适合被标记为早期AD。
