Obrams G I, Grufferman S
Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland 20892.
Cancer Surv. 1991;10:91-102.
The excess of NHL associated with HIV infection is well established. Clinically, HIV associated NHL is characterized by histological evidence of a high grade of malignancy, B cell origin, extensive extranodal involvement (most notably of the CNS) and poor prognosis. High grade B cell lymphoma or primary brain lymphoma in HIV infected individuals is considered diagnostic of AIDS by the Centers for Disease Control. The incidence of NHL among individuals with AIDS varies by subtype of lymphoma, age, sex, race and risk group. Younger individuals, males, whites and haemophiliacs are at higher risk than other groups. The incidence of HIV associated NHL is increasing. Because of the paucity of data on risk factors for this malignancy, the current possibilities for risk modification are limited to the prevention of HIV infection.
与HIV感染相关的非霍奇金淋巴瘤（NHL）发病率过高已得到充分证实。临床上，HIV相关的NHL具有恶性程度高的组织学证据、B细胞起源、广泛的结外受累（最显著的是中枢神经系统）以及预后不良的特点。HIV感染者中的高级别B细胞淋巴瘤或原发性脑淋巴瘤被疾病控制中心视为艾滋病的诊断依据。艾滋病患者中NHL的发病率因淋巴瘤亚型、年龄、性别、种族和风险组而异。较年轻个体、男性、白人和血友病患者比其他群体风险更高。HIV相关NHL的发病率正在上升。由于关于这种恶性肿瘤危险因素的数据匮乏，目前改变风险的可能性仅限于预防HIV感染。
