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Survival rate and risk factors of mortality among HIV/tuberculosis-coinfected patients with and without antiretroviral therapy.接受和未接受抗逆转录病毒治疗的HIV/结核合并感染患者的生存率及死亡风险因素
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Virological response to highly active antiretroviral therapy is unaffected by antituberculosis therapy.高效抗逆转录病毒疗法的病毒学反应不受抗结核治疗的影响。
J Infect Dis. 2006 May 15;193(10):1437-40. doi: 10.1086/503437. Epub 2006 Apr 4.
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The impact of New York City's 1975 fiscal crisis on the tuberculosis, HIV, and homicide syndemic.纽约市1975年财政危机对结核病、艾滋病毒和杀人罪并发流行的影响。
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Acquired rifamycin resistance with twice-weekly treatment of HIV-related tuberculosis.HIV 相关结核病每周两次治疗导致获得性利福平耐药。
Am J Respir Crit Care Med. 2006 Feb 1;173(3):350-6. doi: 10.1164/rccm.200503-417OC. Epub 2005 Aug 18.
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WHO clinical staging of HIV infection and disease, tuberculosis and eligibility for antiretroviral treatment: relationship to CD4 lymphocyte counts.世界卫生组织对艾滋病毒感染与疾病、结核病的临床分期以及抗逆转录病毒治疗的资格：与CD4淋巴细胞计数的关系
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Decline in the AIDS and death rates in the EuroSIDA study: an observational study.欧洲艾滋病临床研究中艾滋病发病率和死亡率的下降：一项观察性研究。
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Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients.南非患者在活动性肺结核治疗期间的人类免疫缺陷病毒1型RNA水平和CD4淋巴细胞计数
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泰国：结核病治疗期间的抗逆转录病毒疗法与艾滋病毒感染患者死亡率显著降低

Antiretroviral therapy during tuberculosis treatment and marked reduction in death rate of HIV-infected patients, Thailand.

作者信息

Akksilp Somsak, Karnkawinpong Opart, Wattanaamornkiat Wanpen, Viriyakitja Daranee, Monkongdee Patama, Sitti Walya, Rienthong Dhanida, Siraprapasiri Taweesap, Wells Charles D, Tappero Jordan W, Varma Jay K

机构信息

Ministry of Public Health, Ubon-ratchathani, Thailand.

出版信息

Emerg Infect Dis. 2007 Jul;13(7):1001-7. doi: 10.3201/eid1307.061506.

DOI:10.3201/eid1307.061506
PMID:18214171
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2878231/
Abstract

Antiretroviral therapy (ART) is lifesaving in patients with advanced HIV infection, but the magnitude of benefit in HIV-infected patients receiving tuberculosis (TB) treatment remains uncertain, and population-based data from developing countries are limited. We prospectively collected data about HIV-infected TB patients from February 2003 through January 2004 in Ubon-ratchathani, Thailand. During 12 months, HIV was diagnosed in 329 (14%) of 2,342 patients registered for TB treatment. Of patients with known outcomes, death during TB treatment occurred in 5 (7%) of 71 who received ART and 94 (43%) of 219 who did not. Using multivariate analysis, we found a large reduction in the odds of death for patients receiving ART before or during TB treatment (odds ratio, 0.2; 95% confidence interval, 0.1-0.5), adjusting for CD4 count, smear status, co-trimoxazole use, and treatment facility. ART is associated with a substantial reduction in deaths during TB treatment for HIV-infected TB patients in Thailand.

摘要

抗逆转录病毒疗法（ART）对晚期HIV感染患者具有救命作用，但HIV感染患者接受结核病（TB）治疗的获益程度仍不确定，且来自发展中国家的基于人群的数据有限。我们于2003年2月至2004年1月在泰国乌汶叻差他尼前瞻性收集了HIV感染的结核病患者的数据。在12个月期间，在登记接受结核病治疗的2342名患者中，有329名（14%）被诊断出感染HIV。在已知结局的患者中，接受ART治疗的71名患者中有5名（7%）在结核病治疗期间死亡，未接受ART治疗的219名患者中有94名（43%）死亡。通过多变量分析，我们发现，在调整了CD4细胞计数、涂片状态、复方新诺明使用情况和治疗机构等因素后，在结核病治疗前或治疗期间接受ART治疗的患者死亡几率大幅降低（优势比为0.2；95%置信区间为0.1 - 0.5）。在泰国，ART与HIV感染的结核病患者在结核病治疗期间的死亡大幅减少相关。