Martins Pedro A L S, Filho Agnaldo Lopes Silva, Fonseca Andrea Moura Rodrigues Maciel, Santos Agostinho, Santos Liliana, Mascarenhas Teresa, Jorge Renato M Natal, Ferreira António J M
IDMEC-Polo FEUP, Faculty of Engineering, University of Porto, Porto, Portugal.
Int Urogynecol J. 2011 Aug;22(8):991-5. doi: 10.1007/s00192-011-1409-0. Epub 2011 Apr 2.
The objective of the present study was to investigate the tensile biomechanical properties of the human female bladder.
Tissue samples were obtained from 13 cadavers without pelvic floor dysfunctions. We performed uniaxial tensile tests to measure the stiffness and maximum stress of the bladder tissue. Correlations were calculated using the Pearson correlation coefficient.
The bladder tissue stiffness ranged from 1 to 4.1 MPa (mean stiffness, 1.9 ± 0.2 MPa) and the maximum stress ranged from 0.5 to 2.6 MPa (mean maximum stress, 0.9 ± 0.1 MPa). There was a strong positive correlation between stiffness and maximum stress in the bladder tissue (ρ = 0.829, p < 0.001). Tissue from women younger than 50 years presented higher bladder stiffness than did tissue from older subjects (2.1 ± 0.2 versus 1.3 ± 0.1 MPa, p = 0.02). Maximum bladder stress, however, was not associated with age (1.0 ± 0.2 versus 0.7 ± 0.1 MPa, p = 0.349). In addition, body mass index and menopausal status were not associated with these biomechanical properties.
Age may influence the uniaxial mechanical behavior of the human female bladder.
本研究的目的是调查人类女性膀胱的拉伸生物力学特性。
从13具无盆底功能障碍的尸体获取组织样本。我们进行单轴拉伸试验以测量膀胱组织的刚度和最大应力。使用Pearson相关系数计算相关性。
膀胱组织刚度范围为1至4.1兆帕（平均刚度，1.9±0.2兆帕），最大应力范围为0.5至2.6兆帕（平均最大应力，0.9±0.1兆帕）。膀胱组织的刚度与最大应力之间存在强正相关（ρ = 0.829，p < 0.001）。50岁以下女性的组织比年长受试者的组织表现出更高的膀胱刚度（2.1±0.2对1.3±0.1兆帕，p = 0.02）。然而，膀胱最大应力与年龄无关（1.0±0.2对0.7±0.1兆帕，p = 0.349）。此外，体重指数和绝经状态与这些生物力学特性无关。
年龄可能影响人类女性膀胱的单轴力学行为。
