Dervisevic Samir, Ijaz Samreen, Chaudry Shahneila, Tedder Richard S
Department of Virology, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom.
Emerg Infect Dis. 2007 Nov;13(11):1689-93. doi: 10.3201/eid1311.070578.
In the United Kingdom, the National Screening Programme for identification of hepatitits B virus (HBV) infection in pregnant women uses HBV e antigen (HBeAg) and antibody to HBeAg (anti-HBe) as markers of infectivity to determine use of immunoglobulin for hepatitis B. Serum samples from 114 HBV-infected women were analyzed. Viral loads correlated with HBeAg/anti-HBe status and viral genotypes. Among 95 mothers whose serum contained anti-HBe, viral loads ranged between undetectable and 8.6 x 10(6) IU/mL (median 228 IU/mL). Ten (10.5%) of these mothers had plasma viral loads >10(4) IU/mL; 6 were infected with genotype E and one each with genotypes A, B, C, and D. All viruses had precore stop codon or basal core promoter mutations. Preponderance of genotypes other than A among antenatal mothers in the United Kingdom reflects increasing globalization and trends in immigration. HBeAg serostatus is no longer sufficiently accurate for inferring potential infectivity of pregnant HBV carriers.
在英国，孕妇乙型肝炎病毒（HBV）感染国家筛查计划使用乙肝e抗原（HBeAg）和乙肝e抗体（抗-HBe）作为传染性标志物，以确定是否使用乙肝免疫球蛋白。对114名HBV感染女性的血清样本进行了分析。病毒载量与HBeAg/抗-HBe状态及病毒基因型相关。在95名血清中含有抗-HBe的母亲中，病毒载量在检测不到至8.6×10⁶IU/mL之间（中位数为228 IU/mL）。其中10名（10.5%）母亲的血浆病毒载量>10⁴IU/mL；6名感染了E基因型，A、B、C和D基因型各1名。所有病毒均有前核心终止密码子或基本核心启动子突变。英国产前母亲中除A基因型外其他基因型占优势，这反映了全球化的加剧和移民趋势。HBeAg血清学状态已不足以准确推断HBV感染孕妇的潜在传染性。
