由球形链霉菌产生的大环四醇类抗生素。
Macrotetrolide antibiotics produced by Streptomyces globisporus.
作者信息
Jizba J, Sedmera P, Zima J, Beran M, Blumauerová M, Kandybin N V, Samoukina G V
机构信息
Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
出版信息
Folia Microbiol (Praha). 1991;36(5):437-43. doi: 10.1007/BF02884062.
Macrotetrolides isolated from a new producer, Streptomyces globisporus, were identified as nonactin, monactin, dinactin and trinactin. Spectroscopic characterization of these compounds was extended by 13NMR spectra. Chemical ionization with ammonia as reactive gas was proposed for mass-spectroscopic characterization of their mixtures. Their biological activity was confirmed by using larvae of the Colorado potato beetle (Leptinotarsa decemlineata) as a new test model.
从新的产生菌球形链霉菌中分离出的大环四内酯类化合物被鉴定为无活菌素、单活菌素、双活菌素和三活菌素。通过13NMR光谱扩展了这些化合物的光谱表征。提出以氨作为反应气体进行化学电离，用于对其混合物进行质谱表征。通过使用科罗拉多马铃薯甲虫（十星瓢虫）幼虫作为新的测试模型，证实了它们的生物活性。
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