Bretherton K N, Day A J, Skinner S L
Atherosclerosis. 1976 Jul-Aug;24(1-2):99-106. doi: 10.1016/0021-9150(76)90067-8.
The entry of [125I]-labelled low density lipoprotein (LDL) into different regions of the aortic intima has been studied over a 6 hour period in both normotensive and renal hypertensive rabbits fed a normal diet. Studies have also been carried out in previously hypertensive rabbits in which the blood pressure was normalized with parenteral hydralazine during the six hour period, in which entry was studied. In the normotensive rabbits entry into the aortic intima was less than 1 mug of LDL protein/100 mg dry defatted weight over the 6 hour period with greatest entry into aortic arch intima and significantly less into both the thoracic and abdominal aortic intimae. Hypertension increased the entry into the arch and into aortic arch intimae. Hypertension increased the entry into the arch and into the thoracic and abdominal segments but this was only statistically significant for the aortic arch. The entry of [125I] LDL into the intima in those rabbits in which the hypertension had been normalized was similar to that for the hypertensive rabbits. The results suggest that hypertension in the normal fed rabbit increases lipoprotein entry into the arterial wall by an effect on vessel wall permeability rather than by a direct effect of filtration pressure.
在6小时内，对喂食正常饮食的正常血压和肾性高血压兔子的主动脉内膜不同区域摄取[125I]标记的低密度脂蛋白（LDL）的情况进行了研究。还对先前患有高血压的兔子进行了研究，在研究摄取情况的6小时期间，通过胃肠外给予肼屈嗪使血压恢复正常。在正常血压的兔子中，在6小时内进入主动脉内膜的LDL蛋白少于1μg/100mg干脱脂重量，进入主动脉弓内膜的量最大，而进入胸主动脉和腹主动脉内膜的量明显较少。高血压增加了进入主动脉弓和主动脉弓内膜的摄取量。高血压增加了进入主动脉弓以及胸段和腹段的摄取量，但这仅在主动脉弓方面具有统计学意义。在高血压已恢复正常的兔子中，[125I]LDL进入内膜的情况与高血压兔子相似。结果表明，正常喂食的兔子中的高血压通过对血管壁通透性的影响而非滤过压的直接作用增加了脂蛋白进入动脉壁的量。
