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[睡眠-觉醒周期与记忆巩固]

[Sleep-wake cycle and memory consolidation].

作者信息

Baratti Carlos M, Boccia Mariano M, Blake Mariano G, Acosta Gabriela B

机构信息

Laboratorio de Neurofarmacología de los procesos de aprendizaje y memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica,UBA.

出版信息

Vertex. 2007 Jul-Aug;18(74):300-4.

Abstract

Although several hypothesis and theories have been advanced as explanations for the functions of sleep, a unified theory of sleep function remains elusive. Sleep has been implicated in the plastic cerebral changes that underlie learning and memory, in particular those related to memory consolidation of recently acquired new information. Despite steady accumulations of positive findings over the last ten years, the precise role of sleep in memory and brain plasticity is unproven at all. This situation might be solved by more integrated approaches that combine behavioral and neurophysiological measurements in well described in vivo models of neuronal activity and brain plasticity.

摘要

尽管已经提出了几种假设和理论来解释睡眠的功能,但统一的睡眠功能理论仍然难以捉摸。睡眠与学习和记忆所依赖的大脑可塑性变化有关,特别是与最近获得的新信息的记忆巩固相关的变化。尽管在过去十年中不断积累了积极的研究结果,但睡眠在记忆和大脑可塑性方面的确切作用根本尚未得到证实。这种情况可能通过更综合的方法来解决,即在描述完善的神经元活动和大脑可塑性体内模型中结合行为学和神经生理学测量。

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