Fernández-Caldas Enrique, Iraola Victor, Carnés Jerónimo
Research & Development Department, Laboratorios LETI, S.L., Tres Cantos, Madrid, Spain.
Protein Pept Lett. 2007;14(10):954-9. doi: 10.2174/092986607782541033.
In recent years, the allergological importance of different mite species not belonging to the family Pyroglyphidae has been demonstrated. These mites, commonly named storage mites, include Lepidoglyphus destructor, Glycyphagus domesticus, Tyrophagus putrescentiae, Acarus siro, Aleuroglyphus ovatus, Suidasia medanensis and Thyreophagus entomophagus. Several allergens from these species have been purified, sequenced and cloned. Many of these allergens have shown sequence homology and a biological function similar to those previously described in Blomia tropicalis and the Dermatophagoides spp. The main allergens described in storage mites include fatty acid binding proteins, tropomysin and paramyosin homologues, apoliphorine like proteins, alfa-tubulines and other, such as group 2, 5 and 7 allergens, which definitive biological function has not been described yet. Besides the purification and characterization of allergens, the allergenicity of other species such as Acarus farris, Austroglycyphagus malaysiensis, Blomia kulagini and B. tjibodas, Cheyletus eruditus, Chortoglyphus arcuatus, Gohieria fusca, Thyreophagus entomophagus and Tyrophagus longior has been investigated. Research has also been conducted to identify allergens in parasitic mites, such as Psoroptes ovis, Sarcoptes scabiei, Varroa jacobsoni, Diplaegidia columbae and Hemisarcoptes cooremani. The allergenicity of mites present in agricultural environments has been investigated. Crossreactivity studies have also been performed to elucidate to what extent all these mites share common, or species specific epitopes. Herein we present a comprehensive review of the allergenicity of mite species which have been implicated in human respiratory and/or dermatological diseases.
近年来，已证实不属于嗜热放线菌科的不同螨类在变应性疾病方面具有重要意义。这些螨类通常被称为仓储螨，包括毁灭嗜鳞螨、家食甜螨、腐食酪螨、粉螨、椭圆食粉螨、梅氏嗜霉螨和食菌嗜渣螨。已对这些螨类的多种变应原进行了纯化、测序和克隆。其中许多变应原已显示出与先前在热带无爪螨和尘螨属中描述的变应原具有序列同源性和相似的生物学功能。仓储螨中描述的主要变应原包括脂肪酸结合蛋白、原肌球蛋白和副肌球蛋白同源物、载脂蛋白样蛋白、α-微管蛋白以及其他一些变应原，如第2、5和7组变应原，其确切的生物学功能尚未明确。除了变应原的纯化和特性研究外，还对其他螨类的变应原性进行了研究，如法氏螨、马来西亚嗜甜螨、库氏柏氏螨和蒂氏柏氏螨、普通肉食螨、弓毛食甜螨、褐色嗜卷螨、食菌嗜渣螨和长食酪螨。也开展了研究以鉴定寄生螨中的变应原，如羊痒螨、疥螨、雅氏瓦螨、鸽双羽螨和库氏半疥螨。已对农业环境中存在的螨类的变应原性进行了研究。还进行了交叉反应性研究，以阐明所有这些螨类在多大程度上共享共同的或物种特异性的表位。在此，我们对与人类呼吸道和/或皮肤病相关的螨类变应原性进行全面综述。
