Dambrink J H, Imholz B P, Karemaker J M, Wieling W
Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands.
Clin Auton Res. 1991 Dec;1(4):281-7. doi: 10.1007/BF01819833.
Neurocardiovascular control during postural change was investigated in two teenage females with complaints of dizziness almost immediately on standing up. Blood pressure and heart rate were monitored continuously with a Finapres device. On standing there was a brief but marked fall in blood pressure between 5-10 s after the onset of the manoeuvre. The maximum fall in systolic and diastolic blood pressure was 65 mmHg and 40 mmHg respectively in the first subject, and 58 mmHg and 29 mmHg respectively in the second subject. In both, postural tachycardia was present after 1-2 min of standing with heart rate increasing by up to 39 beats/min in the first subject and 60 beats/min in the second subject. On a follow-up examination 3 years later these changes had disappeared in the first subject while they persisted in the second subject, when she was studied two years later. We conclude that in these patients initial postural dizziness is related to an excessive fall in blood pressure upon standing.
对两名十几岁女性进行了研究,她们在站立后几乎立即出现头晕症状,以此来探究姿势改变期间的神经心血管控制情况。使用Finapres设备持续监测血压和心率。站立时,在动作开始后的5至10秒内血压出现短暂但明显的下降。第一名受试者收缩压和舒张压的最大降幅分别为65 mmHg和40 mmHg,第二名受试者分别为58 mmHg和29 mmHg。两人在站立1至2分钟后均出现姿势性心动过速,第一名受试者心率增加高达39次/分钟,第二名受试者心率增加60次/分钟。3年后的随访检查中,第一名受试者的这些变化已消失,而第二名受试者的这些变化依然存在,两年后对她进行研究时仍是如此。我们得出结论,在这些患者中,最初的姿势性头晕与站立时血压过度下降有关。