Kien C Lawrence, Bunn Janice Y
Department of Pediatrics, University of Vermont, Burlington, Vermont, USA.
Obesity (Silver Spring). 2008 Jan;16(1):29-33. doi: 10.1038/oby.2007.13.
Because estrogen and testosterone affect transcription factors regulating mitochondrial function, we assessed the effects of gender on the metabolic response to dietary palmitic acid (PA) vs. oleic acid (OA) in subjects participating in a previously described trial.
Adults (N = 43) were studied after following a baseline diet (PA = 8.4% kcal, OA = 13.1% kcal) and after undergoing one of two experimental diets: high PA (HI PA) (PA = 16.8%, OA = 16.4% kcal) (N = 21; 11 men) or high OA (HI OA) (PA = 1.7%, and OA = 31.4%) (N = 22; 11 men).
Relative to baseline, the rate of fatty acid (FA) oxidation (% resting energy expenditure(REE)) (mean +/- s.e.m.) increased in women on HI OA while decreasing on HI PA in the fed (+11.8 +/- 5.6% vs. -6.3 +/- 4.2%, P = 0.02) and fasting states (+13.4 +/- 4.2% vs. -12.7 +/- 6.9%, P = 0.047), but changes in men were not statistically significant. Daily energy expenditure changed only in men, increasing on HI OA and decreasing on HI PA (+66 +/- 61 kcal/day or 1.2 +/- 1.0 kcal/kg fat-free mass (FFM)/day vs. -266 +/- 78 kcal/day or -4.2 +/- 1.3 kcal/kg FFM/day, P = 0.004 and P = 0.007, respectively).
Increased dietary PA/OA caused decreased FA oxidation in women, in the fed and fasted states and decreased daily energy expenditure (DEE) in men.
由于雌激素和睾酮会影响调节线粒体功能的转录因子，我们在参与一项先前描述试验的受试者中评估了性别对饮食中棕榈酸（PA）与油酸（OA）代谢反应的影响。
成年人（N = 43）在遵循基线饮食（PA = 8.4%千卡，OA = 13.1%千卡）后，接受两种实验饮食之一：高PA（HI PA）（PA = 16.8%，OA = 16.4%千卡）（N = 21；11名男性）或高OA（HI OA）（PA = 1.7%，OA = 31.4%）（N = 22；11名男性）。
相对于基线，在进食和空腹状态下，HI OA饮食的女性脂肪酸（FA）氧化率（占静息能量消耗（REE）的百分比）（平均值±标准误）增加，而HI PA饮食的女性则降低（分别为+11.8±5.6%对-6.3±4.2%，P = 0.02；+13.4±4.2%对-12.7±6.9%，P = 0.047），但男性的变化无统计学意义。每日能量消耗仅在男性中发生变化，HI OA饮食时增加，HI PA饮食时减少（分别为+66±61千卡/天或1.2±1.0千卡/千克去脂体重（FFM）/天对-266±78千卡/天或-4.2±1.3千卡/千克FFM/天，P = 0.004和P = 0.007）。
饮食中PA/OA增加导致女性在进食和空腹状态下FA氧化减少，男性每日能量消耗（DEE）减少。
