Kien C Lawrence, Bunn Janice Y, Ugrasbul Figen
Department of Pediatrics, University of Texas Medical Branch and Shriners Hospital for Children, Galveston, TX, USA.
Am J Clin Nutr. 2005 Aug;82(2):320-6. doi: 10.1093/ajcn.82.2.320.
Oleic acid (OA) is oxidized more rapidly than is palmitic acid (PA).
We hypothesized that changing the dietary intakes of PA and OA would affect fatty acid oxidation and energy expenditure.
A double-masked trial was conducted in 43 healthy young adults, who, after a 28-d, baseline, solid-food diet (41% of energy as fat, 8.4% as PA, and 13.1% as OA), were randomly assigned to one of two 28-d formula diets: high PA (40% of energy as fat, 16.8% as PA, and 16.4% as OA; n = 21) or high OA (40% of energy as fat, 1.7% as PA, and 31.4% as OA; n = 22). Differences in the change from baseline were evaluated by analysis of covariance.
In the fed state, the respiratory quotient was lower (P = 0.01) with the high OA (0.86 +/- 0.01) than with the high-PA (0.89 +/- 0.01) diet, and the rate of fat oxidation was higher (P = 0.03) with the high-OA (0.0008 +/- 0.0001) than with the high-PA (0.0005 +/- 0.0001 mg . kg fat-free mass(-1) . min(-1)) diet. Resting energy expenditure in the fed and fasting states was not significantly different between groups. Change in daily energy expenditure in the high-OA group (9 +/- 60 kcal/d) was significantly different from that in the high-PA group (-214 +/- 69 kcal/d; P = 0.02 or 0.04 when expressed per fat-free mass).
Increases in dietary PA decrease fat oxidation and daily energy expenditure, whereas decreases in PA and increases in OA had the opposite effect. Increases in dietary PA may increase the risk of obesity and insulin resistance.
油酸（OA）比棕榈酸（PA）氧化得更快。
我们假设改变PA和OA的膳食摄入量会影响脂肪酸氧化和能量消耗。
对43名健康的年轻成年人进行了一项双盲试验，他们在接受为期28天的基线固体食物饮食（脂肪提供41%的能量，PA提供8.4%的能量，OA提供13.1%的能量）后，被随机分配到两种为期28天的配方饮食中的一种：高PA组（脂肪提供40%的能量，PA提供16.8%的能量，OA提供16.4%的能量；n = 21）或高OA组（脂肪提供40%的能量，PA提供1.7%的能量，OA提供31.4%的能量；n = 22）。通过协方差分析评估与基线相比的变化差异。
在进食状态下，高OA组（0.86±0.01）的呼吸商低于高PA组（0.89±0.01）（P = 0.01），高OA组（0.0008±0.0001）的脂肪氧化速率高于高PA组（0.0005±0.0001毫克·千克去脂体重-1·分钟-1）（P = 0.03）。两组在进食和禁食状态下的静息能量消耗无显著差异。高OA组的每日能量消耗变化（9±60千卡/天）与高PA组（-214±69千卡/天；以去脂体重表示时P = 0.02或0.04）显著不同。
膳食PA的增加会降低脂肪氧化和每日能量消耗，而PA的减少和OA的增加则具有相反的效果。膳食PA的增加可能会增加肥胖和胰岛素抵抗的风险。
