Drosos Georgios I, Kazakos Konstantinos I, Kouzoumpasis Pavlos, Verettas Dionisios-Alexandros
Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece.
Injury. 2007 Sep;38 Suppl 4:S13-21. doi: 10.1016/s0020-1383(08)70005-6.
Demineralised bone matrix (DBM), a form of allograft, possesses the properties of osteoinductivity and osteoconductivity. A large body of data obtained from extensive preclinical studies have clearly supported the utility of DBM in human clinical settings. However, it is now recognized that various DBM configurations may differ considerably with regard to their bone inductive activity. Several factors could account for such variability, including the biologic properties of the graft, the host environment, and the methods of allograft preparation. The differing efficacy of DBM products may also depend on differences in particle size and shape, donor selection criteria, protocols for collection and storage, as well as DBM carrier materials. Several comparative studies have confirmed the differences in the osteoinductive potential of various DBM preparations. The purpose of the present review is to provide a critical overview of the current applications of DBM in a clinical setting.
脱矿骨基质（DBM）是一种同种异体移植形式，具有骨诱导性和骨传导性。从广泛的临床前研究中获得的大量数据明确支持了DBM在人类临床环境中的实用性。然而，现在人们认识到，各种DBM配置在其骨诱导活性方面可能有很大差异。几个因素可以解释这种变异性，包括移植物的生物学特性、宿主环境以及同种异体移植的制备方法。DBM产品不同的疗效也可能取决于颗粒大小和形状、供体选择标准、采集和储存方案以及DBM载体材料的差异。几项比较研究证实了各种DBM制剂在骨诱导潜力方面的差异。本综述的目的是对DBM在临床环境中的当前应用进行批判性概述。
