Ozerova I N, Perova N V, Shchel'tsyna N V, Mamedov M N
Department of Metabolic Disorders, State Research Center for Preventive Medicine, Federal Agency on Health Care and Social Development, Moscow.
Bull Exp Biol Med. 2007 Mar;143(3):320-2. doi: 10.1007/s10517-007-0100-4.
Parameters of HDL (concentrations of cholesterol, apoprotein A1, and phospholipids and phospholipid composition) determining their functional properties were studied in patients with arterial hypertension in combination with other components of metabolic syndrome (abdominal obesity, hyperlipidemia, and impaired glucose tolerance). Patients with isolated arterial hypertension did not differ from the control group by the concentration of apoprotein A1 and HDL cholesterol, but had lower content of HDL phospholipids and changed phospholipid composition: lower ratio of phosphatidylcholine and higher relative contents of lysophosphatidylcholine, sphingomyelin, and phosphatidylethanolamine. Parameters of HDL in patients with arterial hypertension associated with other components of metabolic syndrome did not differ from those in patients with isolated arterial hypertension. The observed changes in HDL in patients with arterial hypertension alone or in combination with other components of metabolic syndrome can impair functional capacity of HDL in reverse cholesterol transport, which increases the risk of atherosclerosis.
在患有动脉高血压并伴有代谢综合征其他组分（腹型肥胖、高脂血症和糖耐量受损）的患者中，研究了决定高密度脂蛋白（HDL）功能特性的参数（胆固醇、载脂蛋白A1、磷脂浓度及磷脂组成）。单纯性动脉高血压患者的载脂蛋白A1和HDL胆固醇浓度与对照组无差异，但HDL磷脂含量较低且磷脂组成发生改变：磷脂酰胆碱比例降低，溶血磷脂酰胆碱、鞘磷脂和磷脂酰乙醇胺的相对含量升高。伴有代谢综合征其他组分的动脉高血压患者的HDL参数与单纯性动脉高血压患者无差异。在单纯性动脉高血压患者或伴有代谢综合征其他组分的患者中观察到的HDL变化，可能会损害HDL在逆向胆固醇转运中的功能，从而增加动脉粥样硬化风险。
