Shaw J J, Ishikawa E A, Lainson R, Braga R R, Silveira F T
Wellcome Parasitology Unit, Belém, Pará, Brazil.
Ann Parasitol Hum Comp. 1991;66(6):243-6. doi: 10.1051/parasite/1991666243.
Leishmania (Viannia) shawi Lainson, Braga, de Souza, Póvoa, Ishikawa & Silveira, 1989, was originally recorded from monkeys (Cebus apella and Chiropotes satanas), sloths (Choloepus didactylus and Bradypus tridactylus) and coatis (Nasua nasua) and the sandfly, Lutzomyia whitmani. With a panel of Leishmania specific monoclonal antibodies, it was found that 30.5% of the Leishmania strains from patients, who had contracted cutaneous leishmaniasis in Pará State, were similar, but not identical to L. (V.) guyanensis. The enzyme profiles of 18 of these strains were determined, and it was found that 12 isolates belonged to the same zymodeme as the type strain of L. (V.) shawi. The other 6 belonged to a second L. (V.) shawi zymodeme that only differed from the other by having a slightly faster PEP band. These results are the first records of infections of L. (V.) shawi in man and suggest that this parasite is probably common in areas of Pará State to the south of the Amazon River.
沙氏利什曼原虫（维氏亚属）（Leishmania (Viannia) shawi），由兰森、布拉加、德索萨、波沃阿、石川和西尔韦拉于1989年首次记录于猴子（僧帽猴和白鼻僧面猴）、树懒（二趾树懒和三趾树懒）、南美浣熊（长鼻浣熊）以及白氏罗蛉中。利用一组利什曼原虫特异性单克隆抗体，发现来自帕拉州患皮肤利什曼病患者的利什曼原虫菌株中有30.5%与圭亚那利什曼原虫（维氏亚属）（L. (V.) guyanensis）相似，但并不完全相同。测定了其中18个菌株的酶谱，发现有12个分离株与沙氏利什曼原虫（维氏亚属）的模式菌株属于同一酶型。另外6个属于沙氏利什曼原虫（维氏亚属）的第二个酶型，与另一个酶型的区别仅在于磷酸烯醇丙酮酸（PEP）带稍快。这些结果是沙氏利什曼原虫（维氏亚属）感染人类的首次记录，表明这种寄生虫可能在亚马逊河南部的帕拉州地区很常见。
