MacAvoy M G, Gottlieb J P, Bruce C J
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Cereb Cortex. 1991 Jan-Feb;1(1):95-102. doi: 10.1093/cercor/1.1.95.
Physiological and behavioral data reported here show an involvement of the primate frontal eye field (FEF) cortex in smooth-pursuit eye movements, in addition to its well-established role in saccadic eye movements. Microstimulation just ventral to the small saccade representation of the FEF elicits eye movements that, in contrast to elicited saccades, have low velocities, continue smoothly without interruption during prolonged stimulation, and are usually directed ipsilaterally to the stimulated hemisphere. Neurons in this region respond in association with smooth-pursuit eye movements and visual motion. Tracking deficits following experimental lesions of the FEF depend critically upon the status of this ventral region: superficial lesions sparing it leave smooth-pursuit eye movements intact, whereas lesions removing it produce substantial deficits in the anticipatory initiation, motion-induced acceleration, asymptotic velocity, and predictive continuation of ipsilateral smooth pursuit.
本文报道的生理和行为数据表明，灵长类动物额叶眼区（FEF）皮层除了在眼球快速运动中发挥已被充分证实的作用外，还参与了平稳跟踪眼球运动。在FEF小扫视表征的正腹侧进行微刺激会引发眼球运动，与引发的扫视不同，这些眼球运动速度较低，在长时间刺激过程中持续平稳且不间断，并且通常指向受刺激半球的同侧。该区域的神经元会随着平稳跟踪眼球运动和视觉运动做出反应。FEF实验性损伤后的跟踪缺陷严重取决于这个腹侧区域的状态：保留该区域的浅层损伤会使平稳跟踪眼球运动保持完好，而切除该区域的损伤会在同侧平稳跟踪的预期启动、运动诱导加速、渐近速度和预测性延续方面产生严重缺陷。
