Uehara T, Fukuda M, Suda M, Ito M, Suto T, Kameyama M, Yamagishi Y, Mikuni M
Department of Psychiatry and Human Behavior, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371-8511, Japan.
Eat Weight Disord. 2007 Dec;12(4):183-90. doi: 10.1007/BF03327596.
This study investigated the characteristics of cerebral oxygenation changes in eating disorders patients (ED) and normal controls during the cognitive tasks, using a highly time-resolved, and non-invasive instrument.
Eleven female patients with anorexia nervosa or bulimia nervosa were recruited, and 11 healthy females participated. The relative concentrations of oxy-hemoglobin [o-Hb] and deoxy-hemoglobin [d-Hb] were measured during word fluency task using multichannel near infrared spectroscopy (NIRS).
The increases of o-Hb and d-Hb during the task were compared between the groups. ED patients showed lower activation and a gradual increase in o-HB during the task. In the frontal, d-HB concentrations decreased during the task in ED patients.
These specific patterns of oxygenation changes may indicate less supply and less demand of cerebral blood volume. Bedside measurements of cerebral oxygenation changes using NIRS are useful on understanding of neurophysiological features of ED.
本研究使用一种高时间分辨率的非侵入性仪器，调查饮食失调患者（ED）和正常对照在认知任务期间脑氧合变化的特征。
招募了11名神经性厌食症或神经性贪食症女性患者，以及11名健康女性参与研究。在词汇流畅性任务期间，使用多通道近红外光谱（NIRS）测量氧合血红蛋白[o-Hb]和脱氧血红蛋白[d-Hb]的相对浓度。
比较了两组在任务期间o-Hb和d-Hb的增加情况。ED患者在任务期间表现出较低的激活水平，且o-HB逐渐增加。在额叶，ED患者在任务期间d-Hb浓度降低。
这些特定的氧合变化模式可能表明脑血容量的供应和需求较少。使用NIRS进行床边脑氧合变化测量有助于了解ED的神经生理特征。
