制造线粒体DNA瓶颈的两种方法。
Two ways to make an mtDNA bottleneck.
作者信息
Khrapko Konstantin
出版信息
Nat Genet. 2008 Feb;40(2):134-5. doi: 10.1038/ng0208-134.
Abstract
Rapid changes in mitochondrial DNA allele frequency between generations have been explained by an ‘mtDNA bottleneck’ in the germ line, and mtDNA aggregates, or nucleoids have been recently proposed to drive such a bottleneck. Now, a new study finds a sharp reduction in mtDNA content in the germ line and suggests that such reduction alone may account for the bottleneck effect.
摘要
线粒体DNA等位基因频率在代际间的快速变化已通过生殖系中的“线粒体DNA瓶颈”得到解释，并且最近有人提出线粒体DNA聚集体或类核驱动了这种瓶颈效应。现在，一项新研究发现生殖系中线粒体DNA含量急剧减少，并表明仅这种减少就可能解释瓶颈效应。
相似文献
1
Two ways to make an mtDNA bottleneck.
Nat Genet. 2008 Feb;40(2):134-5. doi: 10.1038/ng0208-134.
2
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.
Nat Genet. 2008 Feb;40(2):249-54. doi: 10.1038/ng.2007.63. Epub 2008 Jan 27.
3
New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.
PLoS Genet. 2009 Dec;5(12):e1000756. doi: 10.1371/journal.pgen.1000756. Epub 2009 Dec 4.
4
Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number.
Genetics. 2016 Dec;204(4):1423-1431. doi: 10.1534/genetics.116.194035. Epub 2016 Oct 21.
5
The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells.
Nat Genet. 2007 Mar;39(3):386-90. doi: 10.1038/ng1970. Epub 2007 Feb 11.
6
Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.
Nat Genet. 1996 Oct;14(2):146-51. doi: 10.1038/ng1096-146.
7
Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells.
Cell Rep. 2016 Jul 19;16(3):622-30. doi: 10.1016/j.celrep.2016.06.023. Epub 2016 Jun 30.
8
Regulation of mitochondrial DNA accumulation during oocyte growth and meiotic maturation in the mouse.
Reproduction. 2012 Aug;144(2):177-85. doi: 10.1530/REP-12-0113. Epub 2012 May 28.
9
Skewed segregation of the mtDNA nt 8993 (T-->G) mutation in human oocytes.
Am J Hum Genet. 1997 Jun;60(6):1495-501. doi: 10.1086/515453.
10
Relaxed replication of mtDNA: A model with implications for the expression of disease.
Am J Hum Genet. 1999 Apr;64(4):1158-65. doi: 10.1086/302311.
引用本文的文献
1
Mitochondrial diseases: from molecular mechanisms to therapeutic advances.
Signal Transduct Target Ther. 2025 Jan 10;10(1):9. doi: 10.1038/s41392-024-02044-3.
2
Evidence for hybridization-driven heteroplasmy maintained across generations in a ricefish endemic to a Wallacean ancient lake.
Biol Lett. 2024 Mar;20(3):20230385. doi: 10.1098/rsbl.2023.0385. Epub 2024 Mar 20.
3
Heteroplasmy and Individual Mitogene Pools: Characteristics and Potential Roles in Ecological Studies.
Biology (Basel). 2023 Nov 20;12(11):1452. doi: 10.3390/biology12111452.
4
Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy.
Nat Biomed Eng. 2022 Apr;6(4):339-350. doi: 10.1038/s41551-022-00881-7. Epub 2022 Apr 18.
5
Mitochondrial DNA in forensic use.
Emerg Top Life Sci. 2021 Sep 24;5(3):415-426. doi: 10.1042/ETLS20210204.
6
Rolling-Circle Replication in Mitochondrial DNA Inheritance: Scientific Evidence and Significance from Yeast to Human Cells.
Genes (Basel). 2020 May 6;11(5):514. doi: 10.3390/genes11050514.
7
Mitochondrial DNA mutations in renal disease: an overview.
Pediatr Nephrol. 2021 Jan;36(1):9-17. doi: 10.1007/s00467-019-04404-6. Epub 2020 Jan 10.
8
Varied Mechanisms and Models for the Varying Mitochondrial Bottleneck.
Front Cell Dev Biol. 2019 Nov 20;7:294. doi: 10.3389/fcell.2019.00294. eCollection 2019.
9
A Population Phylogenetic View of Mitochondrial Heteroplasmy.
Genetics. 2018 Mar;208(3):1261-1274. doi: 10.1534/genetics.118.300711. Epub 2018 Jan 17.
10
Selection for Mitochondrial Quality Drives Evolution of the Germline.
PLoS Biol. 2016 Dec 20;14(12):e2000410. doi: 10.1371/journal.pbio.2000410. eCollection 2016 Dec.
本文引用的文献
1
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes.
Nat Genet. 2008 Feb;40(2):249-54. doi: 10.1038/ng.2007.63. Epub 2008 Jan 27.
2
The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells.
Nat Genet. 2007 Mar;39(3):386-90. doi: 10.1038/ng1970. Epub 2007 Feb 11.
3
No sex please, we're mitochondria: a hypothesis on the somatic unit of inheritance of mammalian mtDNA.
Bioessays. 2000 Jun;22(6):564-72. doi: 10.1002/(SICI)1521-1878(200006)22:6<564::AID-BIES9>3.0.CO;2-4.
4
Mitochondria and germ-cell death.
Nature. 1999 Jul 8;400(6740):125-6. doi: 10.1038/22026.
5
Germline bottlenecks and the evolutionary maintenance of mitochondrial genomes.
Genetics. 1998 Aug;149(4):2135-46. doi: 10.1093/genetics/149.4.2135.
6
Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA.
Nat Genet. 1996 Oct;14(2):146-51. doi: 10.1038/ng1096-146.
7
Demographic influences on mitochondrial DNA lineage survivorship in animal populations.
J Mol Evol. 1984;20(2):99-105. doi: 10.1007/BF02257369.
Zotero 插件