Custodio Ana Maria G, Santos Fernanda C A, Campos Silvana G P, Vilamaior Patricia S L, Góes Rejane M, Taboga Sebastião R
Department of Cell Biology, Institute of Biology, UNICAMP, Campinas, São Paulo, Brazil.
Anat Rec (Hoboken). 2008 Apr;291(4):463-74. doi: 10.1002/ar.20637.
Different from the classic view, the prostate is not a gland exclusive to the male, also being an organ of the female genital system presenting morphofunctional similarity between human and rodent. Thus structural, ultrastructural, morphometric-stereological features of the female prostate (Skene's paraurethral gland) and steroid serological levels were evaluated during young, adult, and senile ages in the Mongolian gerbil. The morphofunctional precocity of the female gland in comparison with the male gland occurring in young gland is probably associated with the female circulating steroid levels. The hormonal imbalance in senesce coincides with its susceptibility to histopathological lesions, such as epithelial hypertrophy, metaplasia, and intraepithelial neoplasia. Differently than that of males, the aging degeneration of the female gland involves the accumulation of lipofuscin granules. However, the alterations in senile prostate did not damage its functionality. These analyses reinforce the use of this experimental model for the comprehension of glandular morphofunctional aspects with special attention to senescence. Thus, the appreciation of this organ becomes relevant to avoid future discomfort to women's health.
与传统观点不同，前列腺并非男性独有的腺体，它也是女性生殖系统的一个器官，在人类和啮齿动物之间呈现出形态功能上的相似性。因此，在蒙古沙鼠的幼年、成年和老年阶段，对雌性前列腺（斯基恩尿道旁腺）的结构、超微结构、形态计量学 - 体视学特征以及类固醇血清水平进行了评估。与幼年时雄性腺体相比，雌性腺体的形态功能早熟可能与雌性循环类固醇水平有关。衰老过程中的激素失衡与其对组织病理学病变的易感性相一致，如上皮肥大、化生和上皮内瘤变。与雄性不同，雌性腺体的衰老退化涉及脂褐素颗粒的积累。然而，老年前列腺的改变并未损害其功能。这些分析强化了使用这个实验模型来理解腺体形态功能方面，特别是关注衰老过程。因此，认识这个器官对于避免未来对女性健康造成不适变得至关重要。
