Department of Anatomy, Cell Biology, Physiology and Biophysics, Institute of Biology, Campinas State University, UNICAMP, Campinas, SP, Brazil.
Micron. 2011 Oct;42(7):712-7. doi: 10.1016/j.micron.2011.03.011. Epub 2011 Apr 8.
The gerbil female prostate is located paraurethrally and has all the histological components of the male prostate, like secretor epithelium and fibromuscular stroma. This gland, like the prostate in males, is targeted by testosterone action, which promotes morphofunctional development. Furthermore, estrogens are required to maintain the male and female prostate and this gland presents both estrogen receptors (ER-α and ER-β). In the present work the structural and morphometric-stereological and serological aspects, as well as the quantification of the incidence, multiplicity and percentage of acini affected by different lesions were analyzed. Animals were divided into four groups: five adult nuliparous (AN) gerbils; five adult multiparous (AM) gerbils; five senescent nulliparous (SN) gerbils; five senescent multiparous (SM) gerbils, and were weighed and sacrificed by CO(2) inhalation. The ventral prostate was dissected out, weighed and fixed to perform histological and morphometric-stereological analysis and quantification of prostate disorders. A high rate of lesions, mainly dysplasia, was identified in tissue from senescent multiparous and adult multiparous animals. Prostatitis was found mainly in SN animals, while dysplasia, hyperplasia, neoplasia, PIA and adenocarcinoma were common in SM ones. Although the proliferative lesion incidence was high in AN group, it was highest in the SM group. The hormonal events which occur due to the estrous cycle in female gerbils (after and before each pregnancy) may be responsible for the high number of lesions observed in our study and all the data presented herein lead us to assume that pregnancy promotes augmentations in both the incidence and the multiplicity of proliferative disorders in the gerbil female prostate since progesterone levels remain high during pregnancy.
沙鼠的前列腺位于尿道旁，具有与雄性前列腺相同的组织学成分，如分泌上皮和纤维肌肉基质。这种腺体与雄性前列腺一样，受到睾酮作用的影响，促进了形态和功能的发育。此外，雌激素对于维持雄性和雌性前列腺是必需的，而该腺体既存在雌激素受体（ER-α和 ER-β）。在本研究中，我们分析了结构和形态计量立体学以及血清学方面，以及不同病变对腺泡的发生率、多发性和百分比的影响。将动物分为四组：五头成年未产（AN）沙鼠；五头成年多产（AM）沙鼠；五头老年未产（SN）沙鼠；五头老年多产（SM）沙鼠。对它们进行称重，并通过 CO2 吸入处死。取出腹侧前列腺，称重并固定以进行组织学和形态计量立体学分析以及前列腺疾病的定量。在老年多产和成年多产动物的组织中，发现了高比例的病变，主要是发育不良。前列腺炎主要发生在 SN 动物中，而发育不良、增生、肿瘤、PIA 和腺癌则常见于 SM 动物中。虽然 AN 组的增殖病变发生率较高，但在 SM 组中最高。由于雌性沙鼠的发情周期（每次怀孕前后）而发生的激素事件可能是导致我们研究中观察到大量病变的原因，所有这些数据使我们假设怀孕会促进沙鼠雌性前列腺中增殖性疾病的发生率和多发性增加，因为在怀孕期间孕激素水平仍然很高。
