Doubrovinski K, Kruse K
Universität des Saarlandes, Fachrichtung Theoretische Physik, 66041 Saarbrücken, Germany and Max-Planck Institut für Physik komplexer Systeme, Nöthnitzer Str. 38, 01187 Dresden, Germany.
Phys Rev Lett. 2007 Nov 30;99(22):228104. doi: 10.1103/PhysRevLett.99.228104. Epub 2007 Nov 29.
The cytoskeleton is an active network of polar filaments. The activity can lead to the polymerization of filaments at one end and depolymerization at the other. This phenomenon is called treadmilling and is essential for many cellular processes, in particular, the crawling of cells on a substrate. We develop a microscopic theoretical framework for describing systems of treadmilling filaments. We show that such systems can self-organize into structures observed in cell fragments, in particular, asters and moving spots.
细胞骨架是一个由极性细丝组成的活跃网络。这种活性可导致细丝一端发生聚合而另一端发生解聚。这种现象被称为踏车行为，对许多细胞过程至关重要，尤其是细胞在基质上的爬行。我们开发了一个微观理论框架来描述踏车细丝系统。我们表明，这样的系统可以自组织成在细胞碎片中观察到的结构，特别是星状体和移动斑点。
