Smith Aaron C, Williams Robert M
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Angew Chem Int Ed Engl. 2008;47(9):1736-40. doi: 10.1002/anie.200705421.
The three-step conversion of -quinotoxine into quinine, as originally reported by Rabe and Kindler in 1918, has been experimentally verified. This conversion serves to re-affirm the formal total synthesis of quinine reported by Woodward and Doering in 1944. [Image: see text]
1918年拉贝和金德勒最初报道的将喹诺酮转化为奎宁的三步反应已通过实验验证。这一转化再次证实了1944年伍德沃德和多林报道的奎宁的形式全合成。[图片:见原文]