Battaglia Cesare, Mancini Fulvia, Cianciosi Arianna, Busacchi Paolo, Persico Nicola, Paradisi Roberto, Facchinetti Fabio, de Aloysio Domenico
Department of Obstetrics and Gynecology, Alma Mater Studiorum-University of Bologna, Via Massarenti 13, Bologna, Italy.
Fertil Steril. 2009 Jul;92(1):240-9. doi: 10.1016/j.fertnstert.2008.05.018. Epub 2008 Aug 9.
To verify whether healthy daughters with polycystic ovaries (PCO) of patients with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease in comparison with healthy controls.
Prospective observational study.
University hospital.
PATIENT(S): Seventeen eumenorrheic daughters with PCO of patients with PCOS (group 1) and 20 healthy volunteers (group 2) with regular ovulatory cycles.
INTERVENTION(S): Fasting blood sampling, ultrasonographic and Doppler analyses, 24-hour ambulatory blood pressure monitoring.
MAIN OUTCOME MEASURE(S): Medical examination; blood measurement of nitrites and nitrates, biochemical and hormonal parameters; utero-ovarian ultrasonographic analysis and color Doppler evaluation of uterine and stromal ovarian arteries; brachial artery flow-mediated vasodilatation; 24-hour ambulatory blood pressure monitoring. An oral glucose tolerance test was performed to analyze glucose, insulin, and C-peptide levels.
RESULT(S): At Doppler analysis a significantly higher uterine and a lower ovarian artery pulsatility index was found in group 1 compared with group 2. The brachial artery diameter, after the reactive hyperemia, showed a greater vasodilatation in controls in comparison with women with PCO. The 24-hour blood pressure monitoring demonstrated that patients with PCO have significant higher 24-hour, daytime, and nighttime diastolic and mean arterial pressure values than controls. The nitrites and nitrates plasma levels were lower in group 1 compared with group 2. The glucose and insulin plasma values were higher in patients with PCO than in controls.
CONCLUSION(S): Eumenorrheic nonhirsute daughters of patients with PCOS who have PCO appearance on ultrasound have an increased cardiovascular risk.
验证多囊卵巢综合征（PCOS）患者的健康多囊卵巢（PCO）女儿与健康对照相比，患心血管疾病的风险是否增加。
前瞻性观察性研究。
大学医院。
17名PCOS患者的月经正常的PCO女儿（第1组）和20名排卵周期正常的健康志愿者（第2组）。
空腹采血、超声和多普勒分析、24小时动态血压监测。
医学检查；血液中亚硝酸盐和硝酸盐、生化和激素参数的测量；子宫卵巢超声分析以及子宫和卵巢间质动脉的彩色多普勒评估；肱动脉血流介导的血管舒张；24小时动态血压监测。进行口服葡萄糖耐量试验以分析血糖、胰岛素和C肽水平。
在多普勒分析中，第1组子宫动脉搏动指数显著高于第2组，卵巢动脉搏动指数低于第2组。与PCO女性相比，对照组在反应性充血后肱动脉直径显示出更大的血管舒张。24小时血压监测表明，PCO患者的24小时、白天和夜间舒张压及平均动脉压值显著高于对照组。第1组血浆中亚硝酸盐和硝酸盐水平低于第2组。PCO患者的血浆葡萄糖和胰岛素值高于对照组。
PCOS患者月经正常且无多毛症的女儿，超声检查有PCO表现，其心血管风险增加。
