Izumida Michiko, Nagai Masaki, Ohta Akiko, Hashimoto Shuji, Kawado Miyuki, Murakami Yoshitaka, Tada Yuki, Shigematsu Mika, Yasui Yoshinori, Taniguchi Kiyosu
Department of Public Health, Saitama Medical University Faculty of Medicine, 38 Morohongo, Moroyama-machi, Iruma-gun Saitama 350-0495, Japan.
J Epidemiol. 2007 Dec;17 Suppl(Suppl):S42-7. doi: 10.2188/jea.17.s42.
Drug-resistant bacteria have been increasing together with advancement of antimicrobial chemotherapy in recent years. In Japan, the target diseases in the National Epidemiological Surveillance of Infectious Diseases (NESID) include some drug-resistant bacterial infections.
We used the data in the NESID in Japan, 2001-2005. Target diseases were methicillinresistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and multi-drug-resistant Pseudomonas aeruginosa (MDRPA) infections. The numbers of patients reported by sentinel hospitals (about 500) on a monthly basis were observed.
The numbers of patients per month per sentinel hospital of 2001-2005 were 3.37-3.98 in MRSA, 0.96-1.19 in PRSP, and 0.11-0.13 in MDRPA infections. The sex ratios (male / female) of patients were 1.69-1.82, 1.34-1.43, and 1.71-2.52, respectively. More than 50% of all patients were adults aged 70 years or older in MRSA and MDRPA infections, but more than 60% were children under 10 years in PRSP infections. The number of patients per sentinel hospital in MRSA infections showed little variation between months, but evidenced a large variation in PRSP and MDRPA infections. The annual trend in the number of patients per sentinel hospital was increasing significantly for the 5-year period in MRSA and PRSP infections, but not in MDRPA infections.
We revealed sex-age distributions of the patients reported to NESID in Japan, 2001- 2005. An increasing incidence of MRSA and PRSP infections and monthly variation in PRSP and MDRPA infections were observed for the 5-year period. Extended observation would be necessary to confirm these trends and variations.
近年来，随着抗菌化疗的进展，耐药菌一直在增加。在日本，全国传染病流行病学监测（NESID）中的目标疾病包括一些耐药菌感染。
我们使用了2001 - 2005年日本NESID中的数据。目标疾病为耐甲氧西林金黄色葡萄球菌（MRSA）、耐青霉素肺炎链球菌（PRSP）和多重耐药铜绿假单胞菌（MDRPA）感染。观察了哨点医院（约500家）每月报告的患者数量。
2001 - 2005年，每家哨点医院每月的患者数量在MRSA感染中为3.37 - 3.98例，PRSP感染中为0.96 - 1.19例，MDRPA感染中为0.11 - 0.13例。患者的性别比（男性/女性）分别为1.69 - 1.82、1.34 - 1.43和1.71 - 2.52。在MRSA和MDRPA感染中，超过50%的患者为70岁及以上成年人，但在PRSP感染中，超过60%的患者为10岁以下儿童。MRSA感染中每家哨点医院的患者数量在各月间变化不大，但PRSP和MDRPA感染显示出较大变化。在5年期间，每家哨点医院患者数量的年度趋势在MRSA和PRSP感染中显著增加，但在MDRPA感染中未增加。
我们揭示了2001 - 2005年日本向NESID报告的患者的性别年龄分布。在这5年期间，观察到MRSA和PRSP感染的发病率增加以及PRSP和MDRPA感染的月度变化。需要进行更长时间的观察以确认这些趋势和变化。
