Matushansky Igor, Maki Robert G, Cordon-Cardo Carlos
Department of Medicine, Columbia University, New York, New York, USA.
Cell Cycle. 2008 Mar 15;7(6):720-4. doi: 10.4161/cc.7.6.5569. Epub 2008 Jan 3.
The Wnt signal transduction pathway coordinates myriad activities, from development and differentiation to proliferation and tumorigenesis. What is perhaps most remarkable is that Wnt signaling is able to accomplish this diverse set of activities in a cell-specific and differentiation stage-dependent manner. In this review, we will highlight the diverse effect of Wnt signaling on three types of tissue stem cells and their corresponding malignancies.
Wnt信号转导通路协调着无数活动，从发育、分化到增殖和肿瘤发生。也许最值得注意的是，Wnt信号能够以细胞特异性和分化阶段依赖性的方式完成这一系列不同的活动。在这篇综述中，我们将重点介绍Wnt信号对三种类型的组织干细胞及其相应恶性肿瘤的不同影响。
