上皮干细胞：一种基于表观遗传学和 Wnt 信号的观点。
Epithelial stem cells: an epigenetic and Wnt-centric perspective.
机构信息
Department of Biological Chemistry, School of Medicine, University of California, Irvine, California 92697-1700, USA.
出版信息
J Cell Biochem. 2010 Aug 15;110(6):1279-87. doi: 10.1002/jcb.22650.
Abstract
Epithelial stem cells, such as those present in mammalian skin, intestine, or mammary gland, are tissue stem cells capable of both long-term self-renewal and multi-lineage differentiation. Here we review studies implicating epigenetic control mechanisms in mammalian epithelial stem cell development and homeostasis. We also provide an update of recent progresses in the involvement of canonical Wnt signaling and note an interesting link between the Wnt pathway and chromatin regulation in epithelial stem cells. We anticipate that epigenetic and epigenomic studies of these cells will increase exponentially in the near future.
摘要
上皮干细胞，如哺乳动物皮肤、肠道或乳腺中的干细胞，是具有长期自我更新和多谱系分化能力的组织干细胞。本文综述了涉及哺乳动物上皮干细胞发育和稳态的表观遗传控制机制的研究进展。我们还提供了经典 Wnt 信号通路参与的最新进展，并指出上皮干细胞中 Wnt 通路与染色质调控之间存在有趣的联系。我们预计，这些细胞的表观遗传和表观基因组学研究在不久的将来将呈指数级增长。
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