[黄连素对家兔血小板血栓素A2及血浆前列环素合成的影响]
[Effects of berberine on synthesis of platelet TXA2 and plasma PGI2 in rabbits].
作者信息
Huang C G, Chu Z L, Yang Z M
机构信息
Department of Biochemistry, Second Military Medical University, Shanghai, China.
出版信息
Zhongguo Yao Li Xue Bao. 1991 Nov;12(6):526-8.
PMID:1824005
Abstract
Using radioimmunoassay, we found that berberine (0.50 mol.L-1) inhibited dose-dependently collagen-, ADP-, and arachidonic acid (AA)-induced TXA2 release from platelets. Berberine (25 mg.kg-1) iv lowered rabbit plasma level of PGI2 from 0.92 +/- 0.20 to 0.61 +/- 0.08 ng.ml-1 after 60 min. The results suggest that berberine inhibits AA release from cell membrane phospholipids and its metabolism.
摘要
采用放射免疫分析法，我们发现黄连素（0.50mol.L-1）能剂量依赖性地抑制胶原、二磷酸腺苷（ADP）和花生四烯酸（AA）诱导的血小板血栓素A2（TXA2）释放。静脉注射黄连素（25mg.kg-1）60分钟后，兔血浆中前列环素（PGI2）水平从0.92±0.20降至0.61±0.08ng.ml-1。结果表明，黄连素抑制细胞膜磷脂中花生四烯酸的释放及其代谢。
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