[甲基黄酮胺对心肌梗死家兔血浆血栓素A2和前列环素水平的影响]
[Effects of methylflavonolamine on TXA2 and PGI2 plasma levels in rabbits with myocardial infarction].
作者信息
Zhang P, Tang Y Z, Hao Y B, Tao R
机构信息
Department of Pharmacology, Shanxi Medical College, Taiyuan, China.
出版信息
Zhongguo Yao Li Xue Bao. 1993 May;14(3):266-8.
Effects of methylflavonolamine (MFA) on TXA2 and PGI2 plasma levels in rabbits of myocardial infarction were investigated. It was found that TXB2 levels were inhibited by MFA 2.5 or 5.0 mg.kg-1 i.v. while 6-keto-PGF1 alpha levels were only slightly inhibited after repeated doses of 5.0 mg.kg-1 i.v. within 6 h. This result indicates that MFA exhibit stronger inhibition on cyclo-oxygenase in platelets than in endothelial cells. In addition, the myocardial injury and the size of myocardial infarction were much less in the MFA treated groups than in the control.
研究了甲基黄酮醇胺（MFA）对心肌梗死家兔血浆中血栓素A2（TXA2）和前列环素（PGI2）水平的影响。发现静脉注射2.5或5.0mg·kg-1的MFA可抑制血栓素B2（TXB2）水平，而在6小时内重复静脉注射5.0mg·kg-1后，6-酮-前列腺素F1α（6-keto-PGF1α）水平仅略有抑制。该结果表明，MFA对血小板中环氧化酶的抑制作用强于内皮细胞。此外，MFA治疗组的心肌损伤和心肌梗死面积远小于对照组。
Zotero 插件