一种可移除的硅橡胶弹性体密封件可减少肉芽组织生长，并维持用于灵长类神经生理学的记录室的无菌状态。
A removable silicone elastomer seal reduces granulation tissue growth and maintains the sterility of recording chambers for primate neurophysiology.
作者信息
Spitler Kevin M, Gothard Katalin M
机构信息
College of Medicine, Department of Physiology, The University of Arizona, 1501 North Campbell Avenue, Room 4104, Tucson, AZ 85724, USA.
出版信息
J Neurosci Methods. 2008 Mar 30;169(1):23-6. doi: 10.1016/j.jneumeth.2007.11.026. Epub 2007 Dec 5.
Abstract
The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings.
摘要
对于一系列急性神经生理学记录而言，开颅手术的无菌维护要求严格且耗时，但对珍贵实验动物的健康至关重要。我们已开发出一种方法，用外科级硅橡胶弹性体（Silastic）在气密腔室中密封开颅创口。在这些条件下，开颅创口中的组织以及腔室的内表面均未被细菌占据。硅橡胶弹性体密封剂延缓了硬脑膜上肉芽组织的生长，并减少了为维持神经生理学记录的理想条件所需的操作步骤。
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