School of Biological and Health Systems Engineering, and Arizona State University, Tempe, AZ 85287-9709, USA.
J Neurosci Methods. 2012 May 30;207(1):86-90. doi: 10.1016/j.jneumeth.2012.03.014. Epub 2012 Apr 5.
While neural recording chambers for non-human primates can be purchased commercially, these generic chambers do not contour to the animal's skull. In order to seal gaps, a cap of dental acrylic (methyl methacrylate) is often applied around the chamber. There are multiple disadvantages associated with this method. Applying acrylic delays and further complicates surgical procedure, and overheating during the curing process can cause damage to the bone. Post-surgery, acrylic margins can give rise to bacterial growth and infection. Here we describe a method to develop custom implants which conform to the individual's skull, thereby eliminating the need for acrylic. This method shortens surgery time and significantly improves the hygiene of chamber margins.
虽然可以从商业渠道购买用于非人类灵长类动物的神经记录室，但这些通用的记录室不能贴合动物的头骨。为了密封缝隙，通常会在记录室周围涂上一层牙科用丙烯酸酯（甲基丙烯酸甲酯）。这种方法有多个缺点。涂丙烯酸酯会延迟并进一步复杂化手术过程，而且在固化过程中过热会对骨骼造成损害。手术后，丙烯酸酯边缘会导致细菌生长和感染。在这里，我们描述了一种开发符合个体头骨的定制植入物的方法，从而无需使用丙烯酸酯。这种方法缩短了手术时间，并显著提高了记录室边缘的卫生状况。
