Tomlin Andrew M, Dovey Susan M, Tilyard Murray W
Royal New Zealand College of General Practitioners' Research Unit, Department of General Practice, Dunedin School of Medicine, University of Otago, P.O. Box 913, Dunedin, New Zealand.
Diabetes Res Clin Pract. 2008 May;80(2):244-52. doi: 10.1016/j.diabres.2007.12.017. Epub 2008 Feb 19.
To determine risk factors monitored in primary care that were significantly associated with diabetes complications requiring hospitalization.
We examined clinical and demographic data for 1080 Type 1 and 11,283 Type 2 New Zealand diabetes patients attending a free primary care diabetes examination between 2000 and 2002. Hospital admissions data for the 2 years following the index examination were linked for each patient using a unique National Health Index code. Logistic regression was used to determine odds ratios for the likelihood of developing diabetic complications adjusted for each variable.
In the Type 1 cohort, 222 patients (20.6%) were hospitalized for diabetes complications and 1948 patients (17.3%) in the Type 2 cohort. In both cohorts, patients admitted with diabetes complications had significantly higher mean glycosylated haemoglobin (HbA1c) (p<0.001) and triglyceride levels (p<0.001), urine albumin:creatinine ratios (p<0.001) and duration of diabetes (p<0.01 Type 1: p<0.001 Type 2) than patients not admitted. In Type 2 patients, age, obesity, HbA1c, urine albumin:creatinine ratios, HDL levels and treatment with insulin or oral medication were all associated with increased odds of admission.
Although it is well known that HbA1c is a significant predictor of diabetes complications, this study shows that urine albumin:creatinine ratio, body mass index, triglycerides and high density lipoproteins are also independent predictors of hospitalization for diabetes complications. Attention to all these factors in the primary care setting is indicated if the burden of diabetes complications to hospital services is to be minimized.
确定在初级保健中监测到的与需要住院治疗的糖尿病并发症显著相关的风险因素。
我们检查了2000年至2002年间参加免费初级保健糖尿病检查的1080例1型和11283例2型新西兰糖尿病患者的临床和人口统计学数据。使用唯一的国民健康指数代码为每位患者链接了索引检查后2年的住院数据。采用逻辑回归确定经每个变量调整后发生糖尿病并发症可能性的比值比。
在1型队列中,222例患者(20.6%)因糖尿病并发症住院,2型队列中有1948例患者(17.3%)。在两个队列中,因糖尿病并发症入院的患者糖化血红蛋白(HbA1c)、甘油三酯水平、尿白蛋白:肌酐比值和糖尿病病程的平均水平均显著高于未入院患者(1型:p<0.001;2型:p<0.001)。在2型患者中,年龄、肥胖、HbA1c、尿白蛋白:肌酐比值、高密度脂蛋白水平以及胰岛素或口服药物治疗均与入院几率增加相关。
虽然众所周知HbA1c是糖尿病并发症的重要预测指标,但本研究表明尿白蛋白:肌酐比值、体重指数、甘油三酯和高密度脂蛋白也是糖尿病并发症住院治疗的独立预测指标。如果要将糖尿病并发症对医院服务的负担降至最低,则表明在初级保健环境中应关注所有这些因素。