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颠覆k值:关于在延迟折扣研究中使用半数有效剂量(ED50)的评论

Turning k on its head: comments on use of an ED50 in delay discounting research.

作者信息

Yoon Jin H, Higgins Stephen T

机构信息

Departments of Psychiatry, University of Vermont, Burlington, VT 05401, USA.

出版信息

Drug Alcohol Depend. 2008 May 1;95(1-2):169-72. doi: 10.1016/j.drugalcdep.2007.12.011. Epub 2008 Feb 19.

Abstract

Delay discounting (DD) describes how the value of a reinforcer decreases as delay to its delivery increases. Relationships between DD and various aspects of drug abuse have been demonstrated reliably. A potential barrier to wider adoption of DD techniques is that results are often expressed in terms that may be too abstract or unfamiliar to a broader audience, particularly when describing or comparing hyperbolic DD functions or values of k. In an effort to potentially make DD results more accessible, the current report explores use of an ED50 value in characterizing DD functions, similar to that used in pharmacology research for characterizing dose-effect functions. The ED50 proposed with regard to DD is the delay that is effective in discounting the subjective value of the delayed reinforcer by 50%. Additionally, a convenient method for calculating ED50 values for DD is discussed.

摘要

延迟折扣(DD)描述了强化物的价值如何随着其交付延迟的增加而降低。DD与药物滥用的各个方面之间的关系已得到可靠证明。DD技术更广泛应用的一个潜在障碍是,结果通常以可能过于抽象或不为更广泛受众熟悉的术语来表达,特别是在描述或比较双曲线DD函数或k值时。为了可能使DD结果更容易理解,本报告探讨了使用半数有效剂量(ED50)值来表征DD函数,类似于药理学研究中用于表征剂量效应函数的方法。关于DD提出的ED50是指能将延迟强化物的主观价值折扣50%的延迟时间。此外,还讨论了一种计算DD的ED50值的简便方法。

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