Cleck Jessica N, Blendy Julie A
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6055, USA.
J Clin Invest. 2008 Feb;118(2):454-61. doi: 10.1172/JCI33946.
Sustained exposure to various psychological stressors can exacerbate neuropsychiatric disorders, including drug addiction. Addiction is a chronic brain disease in which individuals cannot control their need for drugs, despite negative health and social consequences. The brains of addicted individuals are altered and respond very differently to stress than those of individuals who are not addicted. In this Review, we highlight some of the common effects of stress and drugs of abuse throughout the addiction cycle. We also discuss both animal and human studies that suggest treating the stress-related aspects of drug addiction is likely to be an important contributing factor to a long-lasting recovery from this disorder.
持续暴露于各种心理压力源会加剧神经精神疾病，包括药物成瘾。成瘾是一种慢性脑部疾病，尽管会产生负面的健康和社会后果，但个体仍无法控制对药物的需求。成瘾个体的大脑发生了改变，对压力的反应与未成瘾个体截然不同。在本综述中，我们强调了压力和滥用药物在整个成瘾周期中的一些常见影响。我们还讨论了动物和人体研究，这些研究表明，治疗药物成瘾中与压力相关的方面可能是实现该疾病长期康复的一个重要因素。
