• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

非血红素铁依赖性双加氧酶:解析复杂酶促氧化反应的催化机制

Non-heme iron-dependent dioxygenases: unravelling catalytic mechanisms for complex enzymatic oxidations.

作者信息

Bugg Timothy D H, Ramaswamy S

机构信息

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.

出版信息

Curr Opin Chem Biol. 2008 Apr;12(2):134-40. doi: 10.1016/j.cbpa.2007.12.007. Epub 2008 Feb 20.

DOI:10.1016/j.cbpa.2007.12.007
PMID:18249197
Abstract

The article reviews recent developments in the study of the reaction mechanisms of non-heme iron-dependent dioxygenase enzymes, especially the catechol dioxygenases and arene (Rieske) dioxygenases.

摘要

本文综述了非血红素铁依赖性双加氧酶反应机制研究的最新进展,特别是儿茶酚双加氧酶和芳烃(里氏)双加氧酶。

相似文献

1
Non-heme iron-dependent dioxygenases: unravelling catalytic mechanisms for complex enzymatic oxidations.非血红素铁依赖性双加氧酶:解析复杂酶促氧化反应的催化机制
Curr Opin Chem Biol. 2008 Apr;12(2):134-40. doi: 10.1016/j.cbpa.2007.12.007. Epub 2008 Feb 20.
2
Quantum chemical studies of dioxygen activation by mononuclear non-heme iron enzymes with the 2-His-1-carboxylate facial triad.具有2-组氨酸-1-羧酸盐面三联体的单核非血红素铁酶对双氧激活的量子化学研究。
Dalton Trans. 2004 Oct 21(20):3153-62. doi: 10.1039/B408340G. Epub 2004 Aug 27.
3
Iron(III) complexes of tripodal monophenolate ligands as models for non-heme catechol dioxygenase enzymes: correlation of dioxygenase activity with ligand stereoelectronic properties.作为非血红素儿茶酚双加氧酶模型的三脚架单酚配体的铁(III)配合物:双加氧酶活性与配体立体电子性质的相关性
Inorg Chem. 2009 Sep 21;48(18):8771-83. doi: 10.1021/ic900969n.
4
Directed evolution of a non-heme-iron-dependent extradiol catechol dioxygenase: identification of mutants with intradiol oxidative cleavage activity.非血红素铁依赖性间苯二酚邻二酚双加氧酶的定向进化:具有间苯二酚氧化裂解活性的突变体的鉴定
Chembiochem. 2006 Dec;7(12):1899-908. doi: 10.1002/cbic.200600296.
5
Acid-base catalysis in the extradiol catechol dioxygenase reaction mechanism: site-directed mutagenesis of His-115 and His-179 in Escherichia coli 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB).间位二醇儿茶酚双加氧酶反应机制中的酸碱催化:大肠杆菌2,3-二羟基苯丙酸1,2-双加氧酶(MhpB)中His-115和His-179的定点诱变
Biochemistry. 2004 Oct 26;43(42):13390-6. doi: 10.1021/bi048518t.
6
Reassessment of the reaction mechanism in the heme dioxygenases.对血红素双加氧酶反应机制的重新评估。
J Am Chem Soc. 2009 Apr 1;131(12):4186-7. doi: 10.1021/ja808326g.
7
Salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans: crystal structure of a peculiar ring-cleaving dioxygenase.来自水杨酸盐氧化假氨基杆菌的水杨酸1,2-双加氧酶:一种特殊的环裂解双加氧酶的晶体结构
J Mol Biol. 2008 Jul 25;380(5):856-68. doi: 10.1016/j.jmb.2008.05.041. Epub 2008 May 24.
8
Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis.3-羟基邻氨基苯甲酸-3,4-双加氧酶的结构研究:参与烟酰胺腺嘌呤二核苷酸生物合成的复杂氧化反应的催化机制
Biochemistry. 2005 May 31;44(21):7632-43. doi: 10.1021/bi047353l.
9
FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus.FtmOx1是一种非血红素铁(II)和α-酮戊二酸依赖性双加氧酶,可催化烟曲霉中疣孢菌素的内过氧化物形成。
Org Biomol Chem. 2009 Oct 7;7(19):4082-7. doi: 10.1039/b908392h. Epub 2009 Aug 6.
10
Spectroscopic and electronic structure studies of 2,3-dihydroxybiphenyl 1,2-dioxygenase: O2 reactivity of the non-heme ferrous site in extradiol dioxygenases.2,3-二羟基联苯1,2-双加氧酶的光谱和电子结构研究:间位二氧合酶中非血红素亚铁位点的O2反应活性
J Am Chem Soc. 2003 Sep 17;125(37):11214-27. doi: 10.1021/ja029746i.

引用本文的文献

1
BTG13-related metalloenzymes: Atypical non-heme iron-dependent dioxygenases with unusual coordination patterns and catalytic mechanisms.与BTG13相关的金属酶:具有异常配位模式和催化机制的非典型非血红素铁依赖性双加氧酶。
Eng Microbiol. 2025 Jan 1;5(1):100188. doi: 10.1016/j.engmic.2024.100188. eCollection 2025 Mar.
2
Bioremediation of Polycyclic Aromatic Hydrocarbons by Means of Bacteria and Bacterial Enzymes.利用细菌和细菌酶对多环芳烃进行生物修复
Microorganisms. 2024 Sep 2;12(9):1814. doi: 10.3390/microorganisms12091814.
3
Baeyer-Villiger oxidation: a promising tool for the synthesis of natural products: a review.
拜耳-维立格氧化反应:一种用于天然产物合成的有前景的工具:综述
RSC Adv. 2024 Jul 25;14(32):23423-23458. doi: 10.1039/d4ra03914a. eCollection 2024 Jul 19.
4
Structural Characterization of the Chlorophyllide a Oxygenase (CAO) Enzyme Through an In Silico Approach.通过计算机模拟方法对叶绿素酸酯a加氧酶(CAO)进行结构表征。
J Mol Evol. 2023 Apr;91(2):225-235. doi: 10.1007/s00239-023-10100-9. Epub 2023 Mar 3.
5
Seeing the -Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in -Dihydroxylation Reactions Modeling Rieske Dioxygenases.看到 -二羟化反应中的中间产物:模拟 Rieske 双加氧酶的 -二羟化反应中单核非血红素铁过氧配合物。
J Am Chem Soc. 2023 Mar 1;145(8):4389-4393. doi: 10.1021/jacs.2c13551. Epub 2023 Feb 16.
6
Contrasting Mechanisms of Aromatic and Aryl-Methyl Substituent Hydroxylation by the Rieske Monooxygenase Salicylate 5-Hydroxylase. Rieske 单加氧酶水杨酸 5-羟化酶对芳烃和芳基-甲基取代基羟化的对比机制。
Biochemistry. 2023 Jan 17;62(2):507-523. doi: 10.1021/acs.biochem.2c00610. Epub 2022 Dec 30.
7
Substrate-Specific Coupling of O Activation to Hydroxylations of Aromatic Compounds by Rieske Non-heme Iron Dioxygenases.赖斯凯非血红素铁双加氧酶将氧活化与芳香族化合物羟基化的底物特异性偶联
ACS Catal. 2022 Jun 3;12(11):6444-6456. doi: 10.1021/acscatal.2c00383. Epub 2022 May 16.
8
Reannotation of Fly Amanita l-DOPA Dioxygenase Gene Enables Its Cloning and Heterologous Expression.对毒蝇伞L-多巴双加氧酶基因的重新注释实现了其克隆与异源表达。
ACS Omega. 2022 Apr 25;7(18):16070-16079. doi: 10.1021/acsomega.2c01365. eCollection 2022 May 10.
9
The Apparently Unreactive Substrate Facilitates the Electron Transfer for Dioxygen Activation in Rieske Dioxygenases.该显然无反应的底物促进 Rieske 双氧酶中氧分子的电子转移活化。
Chemistry. 2022 Mar 16;28(16):e202103937. doi: 10.1002/chem.202103937. Epub 2022 Feb 25.
10
Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, -Dihydroxylation and Epoxidation.单加氧酶和双氧酶催化的通过硫氧化、-二羟基化和环氧化实现噻吩的去芳构化作用。
Int J Mol Sci. 2022 Jan 14;23(2):909. doi: 10.3390/ijms23020909.