Wheaton Lewis A, Bohlhalter Stephan, Nolte Guido, Shibasaki Hiroshi, Hattori Noriaki, Fridman Esteban, Vorbach Sherry, Grafman Jordan, Hallett Mark
Human Motor Control Section, NINDS, NIH, Bethesda, MD 20892-1428, United States.
Neurosci Lett. 2008 Mar 12;433(2):87-92. doi: 10.1016/j.neulet.2007.12.065. Epub 2008 Jan 12.
We sought to determine whether coherent networks which circumvent lesioned cortex are seen in patients with ideomotor apraxia (IMA) while performing tool-use pantomimes. Five normal subjects and five patients with IMA (three patients with corticobasal degeneration and two with left hemisphere stroke) underwent 64-channel EEG recording while performing three tool-use pantomimes with their left hand in a self-paced manner. Beta band (20-22 Hz) coherence indicates that normal subjects have a dominant left hemisphere network responsible for praxis preparation, which was absent in patients. Corticobasal degeneration patients showed significant coherence increase between left parietal-right premotor areas. Left hemisphere stroke patients showed significant coherence increases in a right parietofrontal network. The right hemisphere appears to store useable praxis representations in IMA patients with left hemisphere damage.
我们试图确定在进行工具使用手势模仿时，观念运动性失用症（IMA）患者是否会出现绕过受损皮质的连贯网络。五名正常受试者和五名IMA患者（三名皮质基底节变性患者和两名左半球中风患者）在以自定节奏用左手进行三种工具使用手势模仿时，接受了64导脑电图记录。β频段（20 - 22赫兹）的连贯性表明，正常受试者有一个负责动作准备的占主导地位的左半球网络，而患者中不存在这种网络。皮质基底节变性患者在左顶叶 - 右运动前区之间显示出显著的连贯性增加。左半球中风患者在右侧顶额叶网络中显示出显著的连贯性增加。右半球似乎在左半球受损的IMA患者中存储了可用的动作表征。
