巨红细胞性萎缩性舌炎患者的血液缺乏症、高同型半胱氨酸血症和胃壁细胞抗体阳性。
Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with macrocytosis.
机构信息
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
出版信息
J Formos Med Assoc. 2019 Nov;118(11):1515-1521. doi: 10.1016/j.jfma.2019.07.001. Epub 2019 Jul 16.
BACKGROUND/PURPOSE: Macrocytosis is defined as having the mean corpuscular volume (MCV) ≧ 100 fL. This study evaluated whether 41 atrophic glossitis (AG) patients with macrocytosis had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 532 healthy control subjects or 1064 AG patients.
METHODS
Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 41 AG patients with macrocytosis, 1064 AG patients, and 532 healthy control subjects were measured and compared.
RESULTS
We found that 73.2%, 22.0%, 73.2%, 4.9%, 80.5%, and 56.1% of 41 AG patients with macrocytosis were diagnosed as having blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 41 AG patients with macrocytosis had significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects or 1064 AG patients (all P-values < 0.001). In addition, 41 AG patients with macrocytosis also had significantly higher frequencies of serum iron and folic acid deficiencies than 532 healthy control subjects (both P-values < 0.001). Pernicious anemia was found in 22 AG patients with macrocytosis.
CONCLUSION
There are significantly higher frequencies of anemia and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients with macrocytosis than in healthy control subjects. AG patients with macrocytosis also have significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, hyperhomocysteinemia, and serum GPCA positivity than AG patients.
背景/目的：巨红细胞症的定义为平均红细胞体积（MCV）≧100fL。本研究评估了 41 例巨红细胞症萎缩性舌炎（AG）患者与 532 名健康对照者或 1064 例 AG 患者相比，贫血、血液营养素缺乏、高同型半胱氨酸血症和血清壁细胞抗体（GPCA）阳性率是否更高。
方法
测量并比较了 41 例巨红细胞症 AG 患者、1064 例 AG 患者和 532 名健康对照者的全血细胞计数、血清铁、维生素 B12、叶酸、同型半胱氨酸和 GPCA 水平。
结果
我们发现，41 例巨红细胞症 AG 患者中分别有 73.2%、22.0%、73.2%、4.9%、80.5%和 56.1%被诊断为存在血红蛋白、铁、维生素 B12 和叶酸缺乏、高同型半胱氨酸血症和血清 GPCA 阳性。此外，41 例巨红细胞症 AG 患者的血红蛋白和血清维生素 B12 缺乏、高同型半胱氨酸血症和血清 GPCA 阳性率显著高于 532 名健康对照者或 1064 例 AG 患者（均 P<0.001）。此外，41 例巨红细胞症 AG 患者的血清铁和叶酸缺乏率也显著高于 532 名健康对照者（均 P<0.001）。在 22 例巨红细胞症 AG 患者中发现了恶性贫血。
结论
巨红细胞症 AG 患者的贫血和血清铁、维生素 B12 和叶酸缺乏、高同型半胱氨酸血症和血清 GPCA 阳性率显著高于健康对照者。巨红细胞症 AG 患者的血红蛋白和血清维生素 B12 缺乏、高同型半胱氨酸血症和血清 GPCA 阳性率也显著高于 AG 患者。
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