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相思子中毒的一种不寻常表现:两例报告

An unusual manifestation of Abrus precatorius poisoning: a report of two cases.

作者信息

Subrahmanyan Dharanipragada, Mathew Jomal, Raj Mithun

机构信息

Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

出版信息

Clin Toxicol (Phila). 2008 Feb;46(2):173-5. doi: 10.1080/15563650601185134.

Abstract

Abrus precatorius seeds are highly toxic and are often ingested as a means of suicide in India. Hemorrhagic gastroenteritis with erosions, hemolysis, acute renal damage, hepatotoxicity with elevated liver enzymes, and seizures are common manifestations of toxicity. We report two cases of Abrus precatorius poisoning with raised intracranial pressure (ICP) and papilledema that have not been described earlier in literature. One patient recovered completely with conservative management to lower raised ICP while the other patient expired before effective treatment could be institutedd. The cases are being reported to propose the need for routine fundus examination and brain imaging in severe abrus poisoning with CNS toxicity, as early institution of treatment for cerebral edema measures may be life saving.

摘要

相思子种子毒性极强,在印度常被用作自杀手段。伴有糜烂的出血性肠胃炎、溶血、急性肾损伤、肝酶升高所致的肝毒性以及癫痫发作是中毒的常见表现。我们报告了两例相思子中毒伴颅内压(ICP)升高和视乳头水肿的病例,此前文献中未曾描述过。一名患者通过保守治疗降低升高的ICP后完全康复,而另一名患者在能够实施有效治疗之前死亡。报告这些病例是为了提出,对于伴有中枢神经系统毒性的严重相思子中毒患者,需要进行常规眼底检查和脑部成像,因为早期采取措施治疗脑水肿可能挽救生命。

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