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致命的好奇心:一例通过网络搜索食用相思子企图自杀的案例。

Fatal Curiosity: A Case of Suicidal Attempt by Abrus Seeds Consumption Through Online Research.

作者信息

Kumar Mukesh, Dinkar Prateek Kumar, Abbas Haider, Chaudhary Esha

机构信息

Emergency Medicine, King George's Medical University, Lucknow, IND.

General Medicine, King George's Medical University, Lucknow, IND.

出版信息

Cureus. 2023 May 2;15(5):e38458. doi: 10.7759/cureus.38458. eCollection 2023 May.

DOI:10.7759/cureus.38458
PMID:37273369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10234767/
Abstract

(Jequirity, Indian liquorice, rosary bead, Gunja, or rati)seeds are highly toxic and are often ingested as a means of suicide in India. Gastric symptoms like bleeding, diarrhea, vomiting, and epigastric pain are the common manifestations of this toxicity. Abrin, a toxic substance found in the seeds, is structurally and functionally similar to ricin and is considered even more fatal. We report the first case of  poisoning, where the internet was utilized to procure a potentially deadly poison with the intention to commit suicide in north India. Such actions are relevant to the medical field, particularly regarding the potential risks associated with the unsupervised procurement and misuse of toxic substances. The case highlights the potentially fatal consequences of ingesting Abrus seeds and the need for prompt medical attention in such cases.

摘要

相思子(鸡母珠、印度甘草、念珠豆、相思豆或红豆)种子剧毒,在印度常被用作自杀手段。出血、腹泻、呕吐和上腹部疼痛等胃部症状是这种中毒的常见表现。相思子毒素是种子中发现的一种有毒物质,在结构和功能上与蓖麻毒素相似,被认为更具致命性。我们报告了首例中毒病例,在印度北部有人利用互联网获取一种潜在致命毒药企图自杀。此类行为与医学领域相关,尤其是与无监管地获取和滥用有毒物质的潜在风险有关。该病例凸显了摄入相思子种子的潜在致命后果以及在此类情况下及时就医的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d2f/10234767/6b621fff4010/cureus-0015-00000038458-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d2f/10234767/6b621fff4010/cureus-0015-00000038458-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d2f/10234767/6b621fff4010/cureus-0015-00000038458-i01.jpg

相似文献

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Fatal Curiosity: A Case of Suicidal Attempt by Abrus Seeds Consumption Through Online Research.致命的好奇心:一例通过网络搜索食用相思子企图自杀的案例。
Cureus. 2023 May 2;15(5):e38458. doi: 10.7759/cureus.38458. eCollection 2023 May.
2
Attempted suicide, by mail order: Abrus precatorius.邮购相思豆自杀
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Forensic Sci Med Pathol. 2024 Sep 5. doi: 10.1007/s12024-024-00880-x.
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Abrin poisoning in an 18-month-old child.一名18个月大儿童的相思子毒素中毒事件。
Am J Case Rep. 2015 Mar 10;16:146-8. doi: 10.12659/AJCR.892917.
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Differentiation, Quantification and Identification of Abrin and Agglutinin.蓖麻毒素和凝集素的分化、定量和鉴定。
Toxins (Basel). 2021 Apr 18;13(4):284. doi: 10.3390/toxins13040284.
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An unusual manifestation of Abrus precatorius poisoning: a report of two cases.相思子中毒的一种不寻常表现:两例报告
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Acute demyelinating encephalitis due to Abrus precatorius poisoning--complete recovery after steroid therapy.相思子中毒所致急性脱髓鞘性脑炎——激素治疗后完全康复
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本文引用的文献

1
Computational investigation of phytochemicals from seeds as modulators of peroxisome proliferator-activated receptor gamma (PPARγ).种子中植物化学物质作为过氧化物酶体增殖物激活受体γ(PPARγ)调节剂的计算研究。
J Biomol Struct Dyn. 2023 Jul-Aug;41(12):5568-5582. doi: 10.1080/07391102.2022.2091657. Epub 2022 Jun 30.
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In-vitro antiproliferative efficacy of Abrus precatorius seed extracts on cervical carcinoma.相思豆种子提取物对宫颈癌的体外抗增殖作用。
Sci Rep. 2022 Jun 17;12(1):10226. doi: 10.1038/s41598-022-13976-7.
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Fatal abrin poisoning by injection.
经注射导致致命蓖麻毒素中毒。
Clin Toxicol (Phila). 2021 Feb;59(2):169-171. doi: 10.1080/15563650.2020.1771360. Epub 2020 Jun 1.
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Massive fatal overdose of abrin with progressive encephalopathy.蓖麻毒素致死性超大剂量摄入伴进行性脑病。
Clin Toxicol (Phila). 2020 May;58(5):417-420. doi: 10.1080/15563650.2019.1655150. Epub 2019 Aug 28.
5
Attempted suicide, by mail order: Abrus precatorius.邮购相思豆自杀
J Med Toxicol. 2010 Dec;6(4):427-30. doi: 10.1007/s13181-010-0099-1.
6
An unusual manifestation of Abrus precatorius poisoning: a report of two cases.相思子中毒的一种不寻常表现:两例报告
Clin Toxicol (Phila). 2008 Feb;46(2):173-5. doi: 10.1080/15563650601185134.
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Abrin poisoning.相思子中毒
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Plant-derived abrin-a induces apoptosis in cultured leukemic cell lines by different mechanisms.植物源相思子毒素-a通过不同机制诱导培养的白血病细胞系凋亡。
Toxicol Appl Pharmacol. 2004 Mar 1;195(2):182-93. doi: 10.1016/j.taap.2003.11.018.
9
Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice.向小鼠经肠外注射抗癌植物凝血素相思子毒素和蓖麻毒素后的毒性、分布及消除情况。
Br J Cancer. 1976 Oct;34(4):418-25. doi: 10.1038/bjc.1976.187.
10
On the mechanism of protein-synthesis inhibition by abrin and ricin. Inhibition of the GTP-hydrolysis site on the 60-S ribosomal subunit.关于相思子毒素和蓖麻毒素抑制蛋白质合成的机制。对60-S核糖体亚基上GTP水解位点的抑制作用。
Eur J Biochem. 1975 Nov 15;59(2):573-80. doi: 10.1111/j.1432-1033.1975.tb02484.x.