Tamoglia T W, Hanson S K
Dev Biol Stand. 1976;33:404-9.
TGE seronegative pregnant gilts were vaccinated by intramammary inoculations with a chemically inactivated (betapropiolactone) cell culture virus vaccine and their nursing pigs were exposed to virus at three days of age. The pig morbidity and survival rates were compared with those of pigs nursing gilts exposed orally to virulent TGE virus during late gestation and also with pigs nursing non-vaccinated seronegative sows. The morbidity rates were 100%, 19% and 19%, while the survival rates were 33%, 100% and 17% respectively. The intramammary vaccine used to vaccinate pregnant gilts in this study did not stimulate sufficient antibody response to provide an acceptable level of protection to nursing pigs against experimental challenge with virulent TGE virus. The serum, colostrum and milk TGE neutralizing antibody responses are reported.
用化学灭活（β-丙内酯）细胞培养病毒疫苗经乳腺接种对猪传染性胃肠炎（TGE）血清阴性的妊娠后备母猪进行免疫，其哺乳仔猪在3日龄时接触病毒。将这些仔猪的发病率和存活率与在妊娠后期经口接触强毒TGE病毒的哺乳母猪所产仔猪以及哺乳未免疫血清阴性母猪所产仔猪的发病率和存活率进行比较。发病率分别为100%、19%和19%，而存活率分别为33%、100%和17%。本研究中用于给妊娠后备母猪接种的乳腺疫苗未能刺激产生足够的抗体反应，从而无法为哺乳仔猪提供可接受水平的保护，使其免受强毒TGE病毒的实验性攻击。报告了血清、初乳和乳汁中TGE中和抗体反应情况。
