Lerman A, Click R L, Narr B J, Wiesner R H, Krom R A, Textor S C, Burnett J C
Department of Internal Medicine, Mayo Medical School, Rochester, Minnesota 55905.
Transplantation. 1991 Mar;51(3):646-50. doi: 10.1097/00007890-199103000-00020.
Endothelin (ET) is a 21-amino-acid peptide of endothelial origin, is a potent systemic and renal vasoconstrictor associated with sodium retention and modulation of the renin-angiotensin-aldosterone system. The present study was designed to determine if plasma ET is elevated in humans with cirrhosis (n = 12), a state characterized by sodium retention and increased plasma renin activity (PRA) and plasma aldosterone (PA), and to determine the effect of orthotopic liver transplantation (OLT) upon plasma ET, PRA, and PA at 1, 3, and 7 days after transplantation. Plasma ET before OLT was 1.62 +/- 0.23 pg/ml, which was not different as compared with normal controls. Plasma ET significantly increased to 4.18 +/- 0.66, 3.87 +/- 0.58, and 4.07 +/- 0.61 pg/ml, respectively following OLT. PRA remained elevated throughout the postoperative course, in contrast to PA that decreased following OLT. Mean arterial pressure increased significantly from 82 +/- 4 pre-OLT to 98 +/- 4 and 103 +/- 2 mmHG on days 3 and 7 respectively.
内皮素（ET）是一种源于内皮细胞的21个氨基酸的肽，是一种强效的全身和肾血管收缩剂，与钠潴留以及肾素-血管紧张素-醛固酮系统的调节有关。本研究旨在确定肝硬化患者（n = 12）的血浆ET是否升高，肝硬化是一种以钠潴留、血浆肾素活性（PRA）和血浆醛固酮（PA）升高为特征的状态，并确定原位肝移植（OLT）对移植后1天、3天和7天的血浆ET、PRA和PA的影响。OLT前血浆ET为1.62±0.23 pg/ml，与正常对照组相比无差异。OLT后血浆ET分别显著升高至4.18±0.66、3.87±0.58和4.07±0.61 pg/ml。PRA在术后全过程均保持升高，而PA在OLT后下降。平均动脉压从OLT前的82±4显著升高至术后第3天的98±4和第7天的103±2 mmHg。
