Veglio F, Pinna G, Melchio R, Rabbia F, Panarelli M, Gagliardi B, Chiandussi L
Dipartimento di Medicina e Oncologia Sperimentale, Ospedale San Vito, University of Turin, Italy.
J Hepatol. 1992 May;15(1-2):85-7. doi: 10.1016/0168-8278(92)90016-i.
Endothelin-1, a potent vasoconstrictor peptide with 21 amino acid residues, is released by the vascular endothelium. Plasma immunoreactive endothelin levels were measured in 23 patients with cirrhosis and in 20 healthy subjects. Concentrations were significantly lower in patients with non-uraemic cirrhosis than in normal subjects (19.4 +/- 8.9 pmol/l vs. 48.8 +/- 24.8 pmol/l, p less than 0.002). Plasma renin, aldosterone, atrial natriuretic peptide, arginine-vasopressin and catecholamines did not show significant correlations with plasma endothelin-1 levels. Furthermore, there were no significant differences in plasma endothelin levels for etiology of cirrhosis, presence of ascites or varices. These data suggest that low circulating endothelin may be involved in the development or maintenance of systemic vasodilatation in cirrhosis.
内皮素-1是一种由21个氨基酸残基组成的强效血管收缩肽，由血管内皮释放。对23例肝硬化患者和20名健康受试者的血浆免疫反应性内皮素水平进行了测量。非尿毒症肝硬化患者的浓度显著低于正常受试者（19.4±8.9 pmol/l对48.8±24.8 pmol/l，p<0.002）。血浆肾素、醛固酮、心房利钠肽、精氨酸加压素和儿茶酚胺与血浆内皮素-1水平无显著相关性。此外，肝硬化病因、腹水或静脉曲张的存在与否，血浆内皮素水平均无显著差异。这些数据表明，低循环内皮素可能参与了肝硬化全身血管舒张的发生或维持。
