Küster W, Rödder-Wehrmann O, Plewig G
Hautklinik, Heinrich-Heine-Universität Düsseldorf.
Hautarzt. 1991 Jan;42(1):2-4.
Acne inversa is a chronic inflammatory disorder of sebaceous follicles and terminal hair follicles and is one type of acne diseases. The pathogenesis of acne inversa is identical with that of the other types: Hyperkeratosis of the follicular infundibulum leads to a comedo. Bacterial infections result in a rupture of the follicular canal followed by a granulomatous inflammatory reaction with abscesses, panniculitis and draining sinuses. Acne inversa has so far only occasionally been observed in two or more members of the same family. The familial presentations of acne inversa published in the literature and two observations of familial occurrence among the authors' own patients reveal an autosomal dominant inheritance with high penetrance.
反向性痤疮是一种皮脂腺毛囊和终毛毛囊的慢性炎症性疾病，是痤疮疾病的一种类型。反向性痤疮的发病机制与其他类型相同：毛囊漏斗部的角化过度导致粉刺形成。细菌感染导致毛囊管破裂，随后出现伴有脓肿、脂膜炎和引流窦的肉芽肿性炎症反应。到目前为止，反向性痤疮仅偶尔在同一家族的两名或更多成员中被观察到。文献中发表的反向性痤疮家族病例以及作者自己患者中的两例家族发病观察结果显示其为常染色体显性遗传，且外显率高。
