De Reuck J, Sieben A, Van Maele G
Department of Neurology, University Hospital, Ghent, Belgium.
Eur Neurol. 2008;59(5):225-8. doi: 10.1159/000115635. Epub 2008 Feb 8.
BACKGROUND/AIM: Although most late-onset seizures (LS) appear within 2 years after stroke, some of them occur later and their characteristics are unknown. The aim of this study was to compare the characteristics of patients with very-late-onset seizures (VLS) to those with early-onset seizures (ES) and those with LS.
The study group consisted of 204 patients with stroke-related seizures (29 ES, 128 LS and 47 VLS).
Intracranial haemorrhage was a more frequent cause of ES than of LS and no cause at all of VLS. On the other hand, 25% of the VLS were related to lacunar strokes. Status epilepticus occurred in 20.7% of the ES, in 11.7% of the LS and in 2.1% of the VLS patients. Seizure recurrences were 13.8% in the ES, 54.7% in the LS and 34.0% in the VLS group. Neurological impairment, at stroke onset, and the degree of disability were more severe in patients with ES compared to those with LS and were very mild in the VLS group. The EEG findings as a whole did not show significant differences between the three groups, although a normal EEG was more frequent in the VLS group.
VLS occur in patients with minor ischaemic strokes with good recovery and benign disease course.
背景/目的：虽然大多数迟发性癫痫（LS）在中风后2年内出现，但其中一些出现得更晚，其特征尚不清楚。本研究的目的是比较极迟发性癫痫（VLS）患者与早发性癫痫（ES）患者及LS患者的特征。
研究组由204例与中风相关的癫痫患者组成（29例ES，128例LS和47例VLS）。
颅内出血是ES比LS更常见的病因，而VLS则完全没有病因。另一方面，25%的VLS与腔隙性中风有关。癫痫持续状态在20.7%的ES患者、11.7%的LS患者和2.1%的VLS患者中出现。癫痫复发率在ES组为13.8%，在LS组为54.7%，在VLS组为34.0%。与LS患者相比，ES患者在中风发作时的神经功能损害和残疾程度更严重，而VLS组则非常轻微。尽管VLS组脑电图正常更为常见，但三组脑电图检查结果总体上没有显著差异。
VLS发生于缺血性中风较轻、恢复良好且病程良性的患者。
