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急性呼吸窘迫综合征与知识转化

ARDS and knowledge translation.

作者信息

Liu Mingyao

出版信息

Intensive Care Med. 2008 Apr;34(4):589-91. doi: 10.1007/s00134-007-0965-8. Epub 2008 Feb 9.

DOI:10.1007/s00134-007-0965-8
PMID:18264690
Abstract

Knowledge translation is an important step for translational research. In this issue of Intensive Care Medicine, a new mini-series of basic research-related reviews is published. Three invited reviews focus on the role of extracellular matrix in ventilator-induced lung injury and mechanotransduction. The major challenges in the diagnosis and management of acute respiratory distress syndrome are discussed, which promote further awareness of knowledge translation in intensive care.

摘要

知识转化是转化研究的重要一步。在本期《重症医学》杂志中，发表了一系列新的与基础研究相关的综述。三篇特邀综述聚焦于细胞外基质在呼吸机诱导的肺损伤和机械转导中的作用。文中讨论了急性呼吸窘迫综合征诊断和管理中的主要挑战，这促进了对重症监护中知识转化的进一步认识。

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本文引用的文献

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Differential gene profiling in acute lung injury identifies injury-specific gene expression.急性肺损伤中的差异基因谱分析可识别损伤特异性基因表达。
Crit Care Med. 2008 Mar;36(3):855-65. doi: 10.1097/CCM.0B013E3181659333.
2
The role of proteoglycans in pulmonary edema development.蛋白聚糖在肺水肿形成中的作用。
Intensive Care Med. 2008 Apr;34(4):610-8. doi: 10.1007/s00134-007-0962-y. Epub 2008 Feb 9.
3
Advances in mechanisms of repair and remodelling in acute lung injury.急性肺损伤修复与重塑机制的进展
Intensive Care Med. 2008 Apr;34(4):619-30. doi: 10.1007/s00134-007-0963-x. Epub 2008 Feb 9.
4
Effects of mechanical ventilation on the extracellular matrix.机械通气对细胞外基质的影响。
Intensive Care Med. 2008 Apr;34(4):631-9. doi: 10.1007/s00134-007-0964-9. Epub 2008 Feb 9.
5
Year in review in Intensive Care Medicine, 2006. II. Infections and sepsis, haemodynamics, elderly, invasive and noninvasive mechanical ventilation, weaning, ARDS.《重症医学2006年年回顾》。二、感染与脓毒症、血流动力学、老年患者、有创和无创机械通气、撤机、急性呼吸窘迫综合征
Intensive Care Med. 2007 Feb;33(2):214-29. doi: 10.1007/s00134-006-0512-z. Epub 2007 Jan 13.
6
Mini-series: basic research-related reviews in intensive care medicine.迷你系列：重症监护医学中与基础研究相关的综述
Intensive Care Med. 2007 Jan;33(1):1-2. doi: 10.1007/s00134-006-0434-9. Epub 2006 Nov 9.
7
Src protein tyrosine kinase family and acute inflammatory responses.Src蛋白酪氨酸激酶家族与急性炎症反应。
Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L129-41. doi: 10.1152/ajplung.00261.2005. Epub 2006 Mar 31.
8
Ventilator-induced lung injury: role of protein-protein interaction in mechanosensation.呼吸机诱导的肺损伤：蛋白质-蛋白质相互作用在机械感觉中的作用
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Am J Respir Crit Care Med. 2005 Feb 15;171(4):298-9. doi: 10.1164/rccm.2412002.