Reynolds Matthew R, Ellis Ethan, Zimetbaum Peter
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
J Cardiovasc Electrophysiol. 2008 Jul;19(7):762-8. doi: 10.1111/j.1540-8167.2007.01091.x. Epub 2008 Feb 5.
Quality of life (QoL) is of central importance in atrial fibrillation as both a treatment goal and an endpoint in the evaluation of new therapies. QoL appears to be impaired in the majority of patients with AF. A number of interventions for AF have been shown to improve QoL, including pharmacologic and nonpharmacologic rate control, antiarrhythmic drugs, and nonpharmacologic rhythm control strategies. This paper will review the rationale, design, strengths, and limitations of the questionnaires most commonly used to assess QoL in AF studies, and present QoL outcomes from major studies of AF interventions.
生活质量(QoL)在心房颤动中至关重要,既是治疗目标,也是评估新疗法的终点。大多数房颤患者的生活质量似乎都受到了损害。已证明多种房颤干预措施可改善生活质量,包括药物和非药物心率控制、抗心律失常药物以及非药物节律控制策略。本文将综述房颤研究中最常用于评估生活质量的问卷的基本原理、设计、优点和局限性,并呈现房颤干预主要研究的生活质量结果。