DeLeo Frank R, Otto Michael
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
J Exp Med. 2008 Feb 18;205(2):271-4. doi: 10.1084/jem.20080167. Epub 2008 Feb 11.
Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial infections in the United States. Severe invasive MRSA infections, which include pneumonia, are difficult to treat because the bacteria are resistant to antibiotics. A new report now shows that immunization against alpha-hemolysin (Hla), a cytolytic toxin secreted by most S. aureus strains, protects mice against lethal pneumonia. This finding represents the first successful vaccine strategy for the treatment of staphylococcal pneumonia.
耐甲氧西林金黄色葡萄球菌（MRSA）是美国细菌性感染的主要病因。严重的侵袭性MRSA感染，包括肺炎，难以治疗，因为这种细菌对抗生素具有耐药性。一份新报告显示，针对α-溶血素（Hla）进行免疫接种可保护小鼠免受致死性肺炎的侵害，α-溶血素是大多数金黄色葡萄球菌菌株分泌的一种细胞溶解毒素。这一发现代表了治疗葡萄球菌肺炎的首个成功疫苗策略。
