Silverman D I, Ware J A, Sacks F M, Pasternak R C
Charles A Dana Research Institute, Cardiovascular Division, Beth Israel Hospital, Boston, MA 02215.
Am J Clin Nutr. 1991 May;53(5):1165-70. doi: 10.1093/ajcn/53.5.1165.
To compare their relative absorption and effect on platelet function, concentrated fish oil and tuna were given to 10 subjects in a randomized crossover study. Although plasma enrichment of eicosapentaenoic acid (EPA) from either preparation was similar, relative absorption of EPA from tuna was significantly greater than that from fish oil (46.6 +/- 3.0 mg.L-1.g EPA-1 from tuna compared with 16 +/- 1.0 mg.L-1.g EPA-1 from fish oil, P less than 0.001). Relative absorption of docosahexaenoic acid (DHA) was equivalent (54.0 +/- 9.0 mg.L-1.g DHA-1 from tuna, 56 +/- 9.0 mg.L-1.g DHA-1 from fish oil, NS). Platelet aggregation in response to the endoperoxide analog U46619 was significantly diminished after either preparation but aggregation in response to other agonists, bleeding time, and membrane n-3 (omega-3) fatty acid content were not changed. Thus, n-3 fatty acids are well absorbed after one dose of either tuna or fish oil but EPA absorption appears to be more efficient from tuna. Additionally, a single dose of n-3 fatty acids decreases platelet aggregation by a mechanism not requiring incorporation into platelet membranes.
为比较浓缩鱼油和金枪鱼对血小板功能的相对吸收及影响，在一项随机交叉研究中，对10名受试者给予了浓缩鱼油和金枪鱼。尽管两种制剂中二十碳五烯酸（EPA）的血浆富集程度相似，但金枪鱼中EPA的相对吸收显著高于鱼油（金枪鱼中EPA的相对吸收为46.6±3.0mg·L⁻¹·g EPA⁻¹，鱼油中为16±1.0mg·L⁻¹·g EPA⁻¹，P＜0.001）。二十二碳六烯酸（DHA）的相对吸收相当（金枪鱼中DHA的相对吸收为54.0±9.0mg·L⁻¹·g DHA⁻¹，鱼油中为56±9.0mg·L⁻¹·g DHA⁻¹，无显著差异）。两种制剂给药后，内过氧化物类似物U46619诱导的血小板聚集均显著降低，但其他激动剂诱导的聚集、出血时间及膜n-3（ω-3）脂肪酸含量均未改变。因此，服用一剂金枪鱼或鱼油后，n-3脂肪酸均可被良好吸收，但金枪鱼中EPA的吸收似乎更有效。此外，单剂量的n-3脂肪酸通过一种无需整合入血小板膜的机制降低血小板聚集。
