Urakaze M, Hamazaki T, Makuta M, Ibuki F, Kobayashi S, Yano S, Kumagai A
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Am J Clin Nutr. 1987 Dec;46(6):936-40. doi: 10.1093/ajcn/46.6.936.
An emulsion of fish oil was manufactured to contain 10 g of fish oil/100 mL. Of this, 3 g were eicosapentaenoic acid (EPA) and 1 g was docosahexaenoic acid (DHA). We administered 100 mL of the emulsion into six rabbits intravenously on days 1, 4, 7, 10, and 13. Blood samples were taken on days 0 and 16. The EPA content in phospholipids of plasma, platelets, and red blood cell (RBC) membranes increased 16, 4, and 5 times, respectively. The DHA content in phospholipids of plasma and RBC membranes increased two times whereas that in platelet phospholipids did not increase significantly. Platelet aggregation induced by collagen (10 micrograms/mL) and ADP (5 microM) was depressed significantly after infusion of the fish oil emulsion. In control experiments with soybean oil emulsion, there were almost no significant changes. Therefore, fish oil emulsion may be beneficial to patients who cannot take n-3 fatty acids orally but need them.
制造了一种鱼油乳剂，其鱼油含量为10克/100毫升。其中，3克是二十碳五烯酸（EPA），1克是二十二碳六烯酸（DHA）。在第1、4、7、10和13天，我们给六只兔子静脉注射100毫升该乳剂。在第0天和第16天采集血样。血浆、血小板和红细胞（RBC）膜磷脂中的EPA含量分别增加了16倍、4倍和5倍。血浆和RBC膜磷脂中的DHA含量增加了两倍，而血小板磷脂中的DHA含量没有显著增加。输注鱼油乳剂后，胶原蛋白（10微克/毫升）和ADP（5微摩尔）诱导的血小板聚集显著降低。在大豆油乳剂的对照实验中，几乎没有显著变化。因此，鱼油乳剂可能对不能口服n-3脂肪酸但需要它们的患者有益。
