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1
Correlation between physiological and transforming activities of the c-mos proto-oncogene product and identification of an essential Mos domain for these activities.c-mos原癌基因产物的生理活性与转化活性之间的相关性以及这些活性所必需的Mos结构域的鉴定。
Jpn J Cancer Res. 1991 Mar;82(3):250-3. doi: 10.1111/j.1349-7006.1991.tb01837.x.
2
mos gene transforming efficiencies correlate with oocyte maturation and cytostatic factor activities.mos基因转化效率与卵母细胞成熟及细胞静止因子活性相关。
Mol Cell Biol. 1991 Feb;11(2):604-10. doi: 10.1128/mcb.11.2.604-610.1991.
3
Mouse Mos protooncogene product is present and functions during oogenesis.小鼠Mos原癌基因产物在卵子发生过程中存在并发挥作用。
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5395-9. doi: 10.1073/pnas.86.14.5395.
4
Mutagenic analysis of functional domains of the mos proto-oncogene and identification of the sites important for MAPK activation and DNA binding.mos原癌基因功能域的诱变分析以及对丝裂原活化蛋白激酶（MAPK）激活和DNA结合重要位点的鉴定。
Oncogene. 1995 Oct 19;11(8):1447-57.
5
Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.mos原癌基因的非洲爪蟾同源物可转化哺乳动物成纤维细胞并诱导非洲爪蟾卵母细胞成熟。
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5805-9. doi: 10.1073/pnas.86.15.5805.
6
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.非洲爪蟾卵母细胞减数分裂成熟过程中c-mos原癌基因产物的功能。
Nature. 1988 Oct 6;335(6190):519-25. doi: 10.1038/335519a0.
7
Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos.v-mos癌基因对非洲爪蟾发育的影响：卵母细胞减数分裂诱导及分裂期胚胎有丝分裂停滞
J Cell Biol. 1990 Aug;111(2):533-41. doi: 10.1083/jcb.111.2.533.
8
Oncogenic activation of murine mos protein kinase by DNA rearrangement of its N-terminal coding region.通过其N端编码区的DNA重排实现鼠源mos蛋白激酶的致癌激活。
Oncogene. 1992 Feb;7(2):331-8.
9
The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs.原癌基因c-mos的产物是一种细胞静止因子，负责脊椎动物卵子的减数分裂停滞。
Nature. 1989 Nov 30;342(6249):512-8. doi: 10.1038/342512a0.
10
Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs.非洲爪蟾卵受精后成熟促进因子（MPF）和细胞静止因子（Mos）的独立失活。
Nature. 1991 Jul 18;352(6332):247-8. doi: 10.1038/352247a0.

引用本文的文献

1
Ovarian teratomas in mice lacking the protooncogene c-mos.缺乏原癌基因c-mos的小鼠中的卵巢畸胎瘤。
Jpn J Cancer Res. 1995 Jun;86(6):540-5. doi: 10.1111/j.1349-7006.1995.tb02432.x.
2
The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.Mos/MAP激酶途径通过磷酸化作用使c-Fos稳定，并增强其在NIH 3T3细胞中的转化活性。
EMBO J. 1995 Oct 16;14(20):5048-59. doi: 10.1002/j.1460-2075.1995.tb00187.x.
3
Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor.保守丝氨酸残基的磷酸化并不调节mosxe蛋白激酶诱导卵母细胞成熟或作为细胞静止因子发挥作用的能力。
J Cell Biol. 1992 Feb;116(3):725-35. doi: 10.1083/jcb.116.3.725.
4
Differential occurrence of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblasts.成纤维细胞在细胞周期中Mos的脑脊液样活性和转化活性的差异出现情况。
EMBO J. 1992 Jul;11(7):2447-56. doi: 10.1002/j.1460-2075.1992.tb05309.x.

本文引用的文献

1
Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus.与莫洛尼肉瘤病毒src序列同源的正常小鼠细胞DNA序列（sarc）的特性。
Science. 1980 Mar 14;207(4436):1222-4. doi: 10.1126/science.6243788.
2
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.蛙卵母细胞减数分裂成熟过程中细胞核行为的细胞质调控
J Exp Zool. 1971 Jun;177(2):129-45. doi: 10.1002/jez.1401770202.
3
A new technique for the assay of infectivity of human adenovirus 5 DNA.一种检测人腺病毒5型DNA感染性的新技术。
Virology. 1973 Apr;52(2):456-67. doi: 10.1016/0042-6822(73)90341-3.
4
Expression of c-mos proto-oncogene transcripts in mouse tissues.c-mos原癌基因转录本在小鼠组织中的表达。
Nature. 1985;315(6019):516-8. doi: 10.1038/315516a0.
5
Developmental regulation of ovarian-specific Mos expression.卵巢特异性Mos表达的发育调控。
Oncogene. 1988 Mar;2(3):235-40.
6
The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA.使用硫代磷酸酯修饰的DNA快速高频产生寡核苷酸定向突变。
Nucleic Acids Res. 1985 Dec 20;13(24):8765-85. doi: 10.1093/nar/13.24.8765.
7
Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation.v-mos蛋白假定的ATP结合位点中的赖氨酸残基121是转化所必需的。
Proc Natl Acad Sci U S A. 1985 Dec;82(23):7894-8. doi: 10.1073/pnas.82.23.7894.
8
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.非洲爪蟾卵母细胞减数分裂成熟过程中c-mos原癌基因产物的功能。
Nature. 1988 Oct 6;335(6190):519-25. doi: 10.1038/335519a0.
9
Expression of c-mos RNA in germ cells of male and female mice.c-mos RNA在雄性和雌性小鼠生殖细胞中的表达。
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4509-13. doi: 10.1073/pnas.84.13.4509.
10
Analysis of the transforming potential of the human homolog of mos.
Cell. 1986 Aug 29;46(5):785-94. doi: 10.1016/0092-8674(86)90354-5.

c-mos原癌基因产物的生理活性与转化活性之间的相关性以及这些活性所必需的Mos结构域的鉴定。

Correlation between physiological and transforming activities of the c-mos proto-oncogene product and identification of an essential Mos domain for these activities.

作者信息

Okazaki K, Furuno N, Watanabe N, Ikawa Y, Vande Woude G F, Sagata N

机构信息

Division of Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka.

出版信息

Jpn J Cancer Res. 1991 Mar;82(3):250-3. doi: 10.1111/j.1349-7006.1991.tb01837.x.

DOI:10.1111/j.1349-7006.1991.tb01837.x
PMID:1827090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918402/
Abstract

Using Xenopus eggs and NIH3T3 cells as assay systems, we have compared the physiological (i.e., maturation-inducing and cleavage-arresting) and in vitro transforming activities of the c-mos genes from various species as well as their mutant genes. These analyses show that the three biological activities all depend upon the intrinsic protein kinase activity of Mos and correlate well with each other. Furthermore, our results demonstrate that a well conserved N-terminal 14-amino acid sequence of Mos, termed the Mos-box, is essential for all three activities. These results indicate that the in vitro transforming activity of Mos can be ascribed to the same kinase activity of Mos that exerts the physiological activities.

摘要

我们使用非洲爪蟾卵和NIH3T3细胞作为检测系统，比较了来自不同物种的c-mos基因及其突变基因的生理活性（即成熟诱导和卵裂阻滞活性）和体外转化活性。这些分析表明，这三种生物学活性均依赖于Mos的内在蛋白激酶活性，且相互之间具有良好的相关性。此外，我们的结果表明，Mos的一个高度保守的N端14氨基酸序列（称为Mos盒）对于所有这三种活性至关重要。这些结果表明，Mos的体外转化活性可归因于发挥生理活性的Mos的相同激酶活性。